Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| B cell | 6 studies | 20% ± 2% | |
| regulatory T cell | 6 studies | 17% ± 1% | |
| naive thymus-derived CD8-positive, alpha-beta T cell | 5 studies | 19% ± 1% | |
| plasmacytoid dendritic cell | 5 studies | 25% ± 6% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 18% ± 1% | |
| memory B cell | 4 studies | 17% ± 1% | |
| CD4-positive, alpha-beta memory T cell | 3 studies | 18% ± 3% | |
| CD4-positive, alpha-beta T cell | 3 studies | 20% ± 1% | |
| conventional dendritic cell | 3 studies | 23% ± 6% | |
| epithelial cell | 3 studies | 20% ± 3% | |
| dendritic cell | 3 studies | 26% ± 6% |
Insufficient scRNA-seq data for expression of U2AF1L4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 1080.47 | 180 / 180 | 100% | 4.83 | 429 / 430 |
| brain | 100% | 801.70 | 2633 / 2642 | 99% | 3.90 | 698 / 705 |
| uterus | 100% | 1093.55 | 170 / 170 | 98% | 3.15 | 450 / 459 |
| thymus | 100% | 2214.37 | 653 / 653 | 96% | 3.06 | 579 / 605 |
| adrenal gland | 100% | 1442.02 | 258 / 258 | 95% | 2.82 | 218 / 230 |
| pancreas | 100% | 726.35 | 328 / 328 | 94% | 2.55 | 168 / 178 |
| esophagus | 100% | 879.97 | 1445 / 1445 | 92% | 2.10 | 169 / 183 |
| breast | 100% | 1065.46 | 459 / 459 | 92% | 2.38 | 1030 / 1118 |
| bladder | 100% | 942.14 | 21 / 21 | 92% | 2.59 | 464 / 504 |
| skin | 100% | 626.47 | 1804 / 1809 | 92% | 2.18 | 435 / 472 |
| lung | 100% | 1053.18 | 578 / 578 | 91% | 2.48 | 1054 / 1155 |
| prostate | 100% | 1229.42 | 245 / 245 | 90% | 1.97 | 453 / 502 |
| stomach | 100% | 836.36 | 359 / 359 | 86% | 1.85 | 246 / 286 |
| intestine | 100% | 1044.08 | 966 / 966 | 82% | 1.99 | 434 / 527 |
| kidney | 100% | 1299.04 | 89 / 89 | 81% | 1.98 | 726 / 901 |
| liver | 100% | 874.14 | 226 / 226 | 70% | 1.47 | 284 / 406 |
| adipose | 100% | 945.43 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 9.84 | 29 / 29 |
| spleen | 100% | 1645.81 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.97 | 1 / 1 |
| blood vessel | 100% | 898.41 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 637.40 | 799 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 733.19 | 915 / 929 | 0% | 0 | 0 / 0 |
| heart | 98% | 577.74 | 846 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 2.49 | 38 / 45 |
| eye | 0% | 0 | 0 / 0 | 81% | 1.69 | 65 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000398 | Biological process | mRNA splicing, via spliceosome |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0089701 | Cellular component | U2AF complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005681 | Cellular component | spliceosomal complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030628 | Molecular function | pre-mRNA 3'-splice site binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | U2AF1L4 |
| Protein name | U2 small nuclear RNA auxiliary factor 1 like 4 Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3) |
| Synonyms | U2AF1L3 U2AF1-RS3 |
| Description | FUNCTION: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). . |
| Accessions | ENST00000589429.5 ENST00000601236.1 ENST00000587987.5 K7EJM7 ENST00000591057.5 ENST00000292879.9 [Q8WU68-2] ENST00000587886.2 K7EJH3 ENST00000412391.6 [Q8WU68-1] S4R3L8 S4R353 A0A1D5RMU4 ENST00000378975.8 [Q8WU68-3] ENST00000600296.5 ENST00000594792.5 M0QYK5 Q8WU68 ENST00000591084.5 S4R443 M0R1E1 |