U2AF1L4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of U2AF1L4 at tissue level.

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0016607Cellular componentnuclear speck
GO_0089701Cellular componentU2AF complex
GO_0005654Cellular componentnucleoplasm
GO_0005681Cellular componentspliceosomal complex
GO_0005737Cellular componentcytoplasm
GO_0030628Molecular functionpre-mRNA 3'-splice site binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameU2AF1L4
Protein nameU2 small nuclear RNA auxiliary factor 1 like 4
Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3)
SynonymsU2AF1L3
U2AF1-RS3
DescriptionFUNCTION: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). .

AccessionsENST00000589429.5
ENST00000601236.1
ENST00000587987.5
K7EJM7
ENST00000591057.5
ENST00000292879.9 [Q8WU68-2]
ENST00000587886.2
K7EJH3
ENST00000412391.6 [Q8WU68-1]
S4R3L8
S4R353
A0A1D5RMU4
ENST00000378975.8 [Q8WU68-3]
ENST00000600296.5
ENST00000594792.5
M0QYK5
Q8WU68
ENST00000591084.5
S4R443
M0R1E1