Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 12 studies | 27% ± 9% | |
| astrocyte | 10 studies | 33% ± 18% | |
| microglial cell | 9 studies | 23% ± 7% | |
| adipocyte | 9 studies | 27% ± 7% | |
| glutamatergic neuron | 8 studies | 43% ± 26% | |
| fibroblast | 8 studies | 24% ± 9% | |
| oligodendrocyte | 8 studies | 32% ± 12% | |
| GABAergic neuron | 7 studies | 44% ± 21% | |
| endothelial cell of lymphatic vessel | 6 studies | 24% ± 7% | |
| oligodendrocyte precursor cell | 6 studies | 27% ± 9% | |
| macrophage | 6 studies | 26% ± 8% | |
| epithelial cell | 5 studies | 33% ± 16% | |
| interneuron | 5 studies | 46% ± 26% | |
| cardiac muscle cell | 4 studies | 26% ± 2% | |
| ciliated cell | 4 studies | 20% ± 5% | |
| pericyte | 4 studies | 22% ± 5% | |
| smooth muscle cell | 4 studies | 18% ± 2% | |
| type I pneumocyte | 4 studies | 23% ± 6% | |
| type II pneumocyte | 4 studies | 24% ± 5% | |
| GABAergic interneuron | 3 studies | 19% ± 2% | |
| basal cell | 3 studies | 35% ± 19% | |
| endothelial cell of vascular tree | 3 studies | 25% ± 11% | |
| mast cell | 3 studies | 19% ± 2% | |
| hepatocyte | 3 studies | 39% ± 15% | |
| abnormal cell | 3 studies | 25% ± 9% | |
| T cell | 3 studies | 21% ± 3% | |
| alveolar macrophage | 3 studies | 23% ± 7% | |
| monocyte | 3 studies | 23% ± 5% | |
| lymphocyte | 3 studies | 28% ± 7% | |
| neuron | 3 studies | 45% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 1388.50 | 459 / 459 | 100% | 24.53 | 1118 / 1118 |
| esophagus | 100% | 957.95 | 1445 / 1445 | 100% | 22.88 | 183 / 183 |
| ovary | 100% | 1926.17 | 180 / 180 | 100% | 17.69 | 430 / 430 |
| prostate | 100% | 1423.53 | 245 / 245 | 100% | 23.43 | 502 / 502 |
| stomach | 100% | 863.07 | 359 / 359 | 100% | 21.34 | 286 / 286 |
| lung | 100% | 991.01 | 577 / 578 | 100% | 18.70 | 1155 / 1155 |
| intestine | 100% | 1099.10 | 966 / 966 | 100% | 20.41 | 526 / 527 |
| bladder | 100% | 1279.10 | 21 / 21 | 100% | 16.75 | 503 / 504 |
| uterus | 100% | 1537.13 | 170 / 170 | 100% | 16.52 | 458 / 459 |
| kidney | 100% | 927.07 | 89 / 89 | 100% | 17.24 | 899 / 901 |
| adrenal gland | 100% | 1590.57 | 258 / 258 | 100% | 15.93 | 229 / 230 |
| liver | 100% | 767.89 | 226 / 226 | 100% | 12.55 | 404 / 406 |
| thymus | 100% | 1406.85 | 653 / 653 | 100% | 20.60 | 602 / 605 |
| pancreas | 100% | 657.49 | 328 / 328 | 99% | 16.38 | 177 / 178 |
| brain | 99% | 727.71 | 2623 / 2642 | 100% | 19.20 | 705 / 705 |
| skin | 100% | 1333.57 | 1809 / 1809 | 98% | 20.25 | 464 / 472 |
| adipose | 100% | 1252.20 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1042.37 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 15.44 | 29 / 29 |
| muscle | 100% | 1389.97 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1122.96 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 15.00 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.89 | 1 / 1 |
| heart | 97% | 740.16 | 836 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 90% | 8.85 | 72 / 80 |
| peripheral blood | 80% | 580.30 | 739 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031591 | Biological process | wybutosine biosynthetic process |
| GO_0010181 | Molecular function | FMN binding |
| GO_0102521 | Molecular function | tRNA-4-demethylwyosine synthase activity |
| GO_0051539 | Molecular function | 4 iron, 4 sulfur cluster binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | TYW1 |
| Protein name | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein) tRNA-yW synthesizing protein 1 homolog |
| Synonyms | RSAFD1 |
| Description | FUNCTION: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). . |
| Accessions | ENST00000442959.5 Q9NV66 ENST00000359626.10 [Q9NV66-1] ENST00000361660.8 [Q9NV66-2] C9J9Q4 |