TUT1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TUT1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TUT1 at tissue level.

III. Associated gene sets

GO_0016180Biological processsnRNA processing
GO_0034477Biological processU6 snRNA 3'-end processing
GO_0180010Biological processco-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
GO_0031124Biological processmRNA 3'-end processing
GO_0071044Biological processhistone mRNA catabolic process
GO_0031123Biological processRNA 3'-end processing
GO_0005730Cellular componentnucleolus
GO_0005739Cellular componentmitochondrion
GO_0016607Cellular componentnuclear speck
GO_0005847Cellular componentmRNA cleavage and polyadenylation specificity factor complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0019899Molecular functionenzyme binding
GO_1990817Molecular functionpoly(A) RNA polymerase activity
GO_0140767Molecular functionenzyme-substrate adaptor activity
GO_0017070Molecular functionU6 snRNA binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0050265Molecular functionRNA uridylyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTUT1
Protein nameTerminal uridylyl transferase 1 U6 snRNA-specific isoform 1
Terminal uridylyl transferase 1 U6 snRNA-specific isoform 2
Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52)
Speckle targeted PIP5K1A-regulated poly(A) polymerase (EC 2.7.7.19) (EC 2.7.7.52) (RNA-binding motif protein 21) (U6 snRNA-specific terminal uridylyltransferase 1)
Terminal uridylyl transferase 1, U6 snRNA-specific
SynonymsRBM21
DescriptionFUNCTION: Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs . Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 . In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs . In addition to adenylyltransferase activity, also has uridylyltransferase activity . However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase . Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA . Not involved in replication-dependent histone mRNA degradation. .

AccessionsF5H0R1
ENST00000278279.7
ENST00000308436.11
F8WA97
Q9H6E5
C9JBX0
A0A0S2Z5Y5
ENST00000494385.1
ENST00000476907.6
J3KN81
ENST00000478537.1
A0A0S2Z5L2