TTLL7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018095Biological processprotein polyglutamylation
GO_0007399Biological processnervous system development
GO_0030154Biological processcell differentiation
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0043204Cellular componentperikaryon
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0005874Cellular componentmicrotubule
GO_0030425Cellular componentdendrite
GO_0070740Molecular functiontubulin-glutamic acid ligase activity
GO_0048487Molecular functionbeta-tubulin binding
GO_0043014Molecular functionalpha-tubulin binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameTTLL7
Protein nameTubulin polyglutamylase TTLL7 (EC 6.3.2.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7)
Tubulin tyrosine ligase like 7
TTLL7 protein
Synonyms
DescriptionFUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin . Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction . Preferentially modifies the beta-tubulin tail over an alpha-tail . Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity). .

AccessionsENST00000610996.1
A0A087X234
F2Z2X2
F2Z2J7
ENST00000474957.5
ENST00000260505.13 [Q6ZT98-1]
I6L9D0
Q8TC09
ENST00000485638.5
ENST00000480174.5 [Q6ZT98-2]
Q6ZT98