Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 16 studies | 81% ± 15% | |
smooth muscle cell | 14 studies | 30% ± 12% | |
oligodendrocyte precursor cell | 13 studies | 38% ± 16% | |
glutamatergic neuron | 12 studies | 66% ± 20% | |
ciliated cell | 11 studies | 27% ± 8% | |
GABAergic neuron | 11 studies | 56% ± 22% | |
type I pneumocyte | 10 studies | 33% ± 12% | |
neuron | 8 studies | 42% ± 16% | |
amacrine cell | 7 studies | 32% ± 14% | |
retinal ganglion cell | 7 studies | 54% ± 20% | |
retinal rod cell | 7 studies | 30% ± 5% | |
interneuron | 6 studies | 61% ± 16% | |
retina horizontal cell | 6 studies | 33% ± 11% | |
pericyte | 6 studies | 21% ± 6% | |
astrocyte | 5 studies | 37% ± 12% | |
endothelial cell | 5 studies | 48% ± 13% | |
retinal bipolar neuron | 5 studies | 41% ± 11% | |
retinal cone cell | 5 studies | 30% ± 9% | |
glial cell | 4 studies | 33% ± 12% | |
granule cell | 4 studies | 53% ± 10% | |
fibroblast | 4 studies | 22% ± 4% | |
OFF-bipolar cell | 4 studies | 39% ± 7% | |
ON-bipolar cell | 4 studies | 44% ± 6% | |
GABAergic interneuron | 3 studies | 58% ± 2% | |
epithelial cell | 3 studies | 24% ± 3% | |
microglial cell | 3 studies | 39% ± 6% | |
GABAergic amacrine cell | 3 studies | 33% ± 13% | |
glycinergic amacrine cell | 3 studies | 26% ± 3% | |
rod bipolar cell | 3 studies | 36% ± 7% | |
ependymal cell | 3 studies | 46% ± 14% | |
Schwann cell | 3 studies | 31% ± 10% | |
adipocyte | 3 studies | 23% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 6919.56 | 2632 / 2642 | 100% | 16.64 | 702 / 705 |
prostate | 99% | 2564.33 | 242 / 245 | 99% | 7.42 | 498 / 502 |
pancreas | 95% | 1729.56 | 313 / 328 | 82% | 3.09 | 146 / 178 |
uterus | 96% | 2718.13 | 164 / 170 | 72% | 4.14 | 330 / 459 |
bladder | 100% | 2913.05 | 21 / 21 | 52% | 1.95 | 263 / 504 |
lung | 85% | 1402.04 | 492 / 578 | 63% | 2.41 | 723 / 1155 |
esophagus | 70% | 2876.45 | 1016 / 1445 | 74% | 3.14 | 136 / 183 |
breast | 53% | 653.01 | 242 / 459 | 79% | 3.10 | 880 / 1118 |
stomach | 87% | 1685.90 | 313 / 359 | 43% | 2.08 | 122 / 286 |
intestine | 75% | 1650.63 | 722 / 966 | 32% | 0.95 | 169 / 527 |
blood vessel | 100% | 8450.00 | 1334 / 1335 | 0% | 0 | 0 / 0 |
kidney | 24% | 310.84 | 21 / 89 | 76% | 2.98 | 687 / 901 |
thymus | 62% | 800.49 | 407 / 653 | 37% | 0.84 | 222 / 605 |
adrenal gland | 9% | 113.64 | 22 / 258 | 82% | 6.99 | 188 / 230 |
skin | 18% | 203.32 | 333 / 1809 | 55% | 2.34 | 260 / 472 |
tonsil | 0% | 0 | 0 / 0 | 67% | 1.89 | 30 / 45 |
adipose | 65% | 1028.05 | 786 / 1204 | 0% | 0 | 0 / 0 |
muscle | 63% | 907.67 | 507 / 803 | 0% | 0 | 0 / 0 |
ovary | 22% | 490.87 | 39 / 180 | 38% | 0.96 | 162 / 430 |
heart | 51% | 847.76 | 442 / 861 | 0% | 0 | 0 / 0 |
liver | 13% | 124.82 | 29 / 226 | 34% | 0.93 | 140 / 406 |
lymph node | 0% | 0 | 0 / 0 | 10% | 0.38 | 3 / 29 |
spleen | 4% | 44.64 | 10 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 3% | 0.05 | 2 / 80 |
peripheral blood | 0% | 2.74 | 3 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0018095 | Biological process | protein polyglutamylation |
GO_0007399 | Biological process | nervous system development |
GO_0030154 | Biological process | cell differentiation |
GO_0000226 | Biological process | microtubule cytoskeleton organization |
GO_0043204 | Cellular component | perikaryon |
GO_0005929 | Cellular component | cilium |
GO_0005829 | Cellular component | cytosol |
GO_0005874 | Cellular component | microtubule |
GO_0030425 | Cellular component | dendrite |
GO_0070740 | Molecular function | tubulin-glutamic acid ligase activity |
GO_0048487 | Molecular function | beta-tubulin binding |
GO_0043014 | Molecular function | alpha-tubulin binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0015631 | Molecular function | tubulin binding |
Gene name | TTLL7 |
Protein name | Tubulin polyglutamylase TTLL7 (EC 6.3.2.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7) Tubulin tyrosine ligase like 7 TTLL7 protein |
Synonyms | |
Description | FUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin . Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction . Preferentially modifies the beta-tubulin tail over an alpha-tail . Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity). . |
Accessions | ENST00000610996.1 A0A087X234 F2Z2X2 F2Z2J7 ENST00000474957.5 ENST00000260505.13 [Q6ZT98-1] I6L9D0 Q8TC09 ENST00000485638.5 ENST00000480174.5 [Q6ZT98-2] Q6ZT98 |