TTLL5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018095Biological processprotein polyglutamylation
GO_0060041Biological processretina development in camera-type eye
GO_0036211Biological processprotein modification process
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0005813Cellular componentcentrosome
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0005634Cellular componentnucleus
GO_0070740Molecular functiontubulin-glutamic acid ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameTTLL5
Protein nameTubulin--tyrosine ligase-like protein 5
Tubulin tyrosine ligase like 5
TTLL5 protein
Tubulin polyglutamylase TTLL5 (EC 6.3.2.-) (SRC1 and TIF2-associated modulatory protein) (STAMP protein) (Tubulin--tyrosine ligase-like protein 5)
SynonymsSTAMP
KIAA0998
DescriptionFUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules . Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction . .

AccessionsENST00000298832.14 [Q6EMB2-1]
A0A087WUG0
ENST00000556977.5
ENST00000556893.5 [Q6EMB2-2]
G3V4R8
ENST00000557636.5
ENST00000554510.5
Q6EMB2
G3V2J9
Q2TAY9
A0PJ69
ENST00000286650.9 [Q6EMB2-3]
ENST00000555018.3