TTLL12 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TTLL12 at tissue level.

III. Associated gene sets

GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0036211Biological processprotein modification process
GO_0007346Biological processregulation of mitotic cell cycle
GO_0045087Biological processinnate immune response
GO_0005813Cellular componentcentrosome
GO_0030496Cellular componentmidbody
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005819Cellular componentspindle
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990889Molecular functionH4K20me3 modified histone binding
GO_0005524Molecular functionATP binding
GO_0140943Molecular functionhistone H4K20 trimethyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0004835Molecular functiontubulin-tyrosine ligase activity
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameTTLL12
Protein nameTubulin tyrosine ligase like 12
Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12)
SynonymsKIAA0153
DescriptionFUNCTION: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues . Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) . Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability . During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE . .

AccessionsV9GY16
ENST00000494035.1
Q14166
ENST00000216129.7