TTF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006363Biological processtermination of RNA polymerase I transcription
GO_0006353Biological processDNA-templated transcription termination
GO_0008156Biological processnegative regulation of DNA replication
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameTTF1
Protein nameTranscription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I)
Transcription termination factor 1
Synonyms
DescriptionFUNCTION: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. .

AccessionsENST00000334270.3
Q15361
A0A087WY09
ENST00000612514.4