TSPYL5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TSPYL5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TSPYL5 at tissue level.

III. Associated gene sets

GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0071480Biological processcellular response to gamma radiation
GO_0006334Biological processnucleosome assembly
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameTSPYL5
Protein nameTestis-specific Y-encoded-like protein 5 (TSPY-like protein 5)
SynonymsKIAA1750
DescriptionFUNCTION: Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. .

AccessionsQ86VY4
ENST00000322128.5