TSPAN33 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TSPAN33 at tissue level.

III. Associated gene sets

GO_0072659Biological processprotein localization to plasma membrane
GO_0046931Biological processpore complex assembly
GO_0051604Biological processprotein maturation
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005912Cellular componentadherens junction
GO_0097197Cellular componenttetraspanin-enriched microdomain
GO_0046930Cellular componentpore complex
GO_0005886Cellular componentplasma membrane
GO_0019899Molecular functionenzyme binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTSPAN33
Protein nameTetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)
SynonymsPEN
DescriptionFUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates . Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity . Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 . .

AccessionsQ86UF1
ENST00000486685.3