Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 10 studies | 31% ± 12% | |
endothelial cell | 9 studies | 24% ± 10% | |
capillary endothelial cell | 7 studies | 24% ± 7% | |
epithelial cell | 6 studies | 27% ± 8% | |
adipocyte | 6 studies | 22% ± 5% | |
ciliated cell | 5 studies | 27% ± 5% | |
type I pneumocyte | 5 studies | 28% ± 9% | |
goblet cell | 5 studies | 31% ± 7% | |
endothelial cell of lymphatic vessel | 4 studies | 22% ± 5% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 19% ± 2% | |
basal cell | 4 studies | 25% ± 3% | |
macrophage | 3 studies | 16% ± 0% |
Insufficient scRNA-seq data for expression of TSPAN15 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 100% | 4605.68 | 965 / 966 | 99% | 142.60 | 520 / 527 |
stomach | 100% | 3581.86 | 359 / 359 | 98% | 118.80 | 281 / 286 |
breast | 100% | 4952.03 | 459 / 459 | 98% | 165.73 | 1095 / 1118 |
prostate | 100% | 3043.87 | 245 / 245 | 97% | 81.01 | 488 / 502 |
lung | 99% | 2965.21 | 574 / 578 | 96% | 86.68 | 1114 / 1155 |
bladder | 100% | 3762.95 | 21 / 21 | 95% | 113.72 | 480 / 504 |
uterus | 95% | 2316.04 | 162 / 170 | 95% | 75.45 | 434 / 459 |
brain | 90% | 1998.37 | 2382 / 2642 | 87% | 42.90 | 612 / 705 |
kidney | 99% | 1666.47 | 88 / 89 | 76% | 36.63 | 686 / 901 |
pancreas | 74% | 873.74 | 243 / 328 | 96% | 148.75 | 171 / 178 |
esophagus | 84% | 2510.37 | 1212 / 1445 | 76% | 63.64 | 139 / 183 |
thymus | 95% | 1267.95 | 618 / 653 | 54% | 16.52 | 327 / 605 |
ovary | 11% | 128.94 | 19 / 180 | 97% | 65.60 | 418 / 430 |
adipose | 100% | 5015.39 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 2189.66 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 365.40 | 1 / 1 |
skin | 51% | 495.26 | 925 / 1809 | 41% | 13.91 | 194 / 472 |
tonsil | 0% | 0 | 0 / 0 | 87% | 40.07 | 39 / 45 |
heart | 62% | 539.89 | 534 / 861 | 0% | 0 | 0 / 0 |
muscle | 55% | 672.88 | 443 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 55% | 703.75 | 728 / 1335 | 0% | 0 | 0 / 0 |
adrenal gland | 25% | 175.38 | 65 / 258 | 27% | 10.33 | 61 / 230 |
liver | 4% | 37.53 | 10 / 226 | 30% | 34.25 | 121 / 406 |
lymph node | 0% | 0 | 0 / 0 | 21% | 7.31 | 6 / 29 |
eye | 0% | 0 | 0 / 0 | 11% | 2.59 | 9 / 80 |
peripheral blood | 1% | 8.88 | 12 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008593 | Biological process | regulation of Notch signaling pathway |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_0045746 | Biological process | negative regulation of Notch signaling pathway |
GO_0051043 | Biological process | regulation of membrane protein ectodomain proteolysis |
GO_0051604 | Biological process | protein maturation |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0009986 | Cellular component | cell surface |
GO_0030054 | Cellular component | cell junction |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0016604 | Cellular component | nuclear body |
GO_0031902 | Cellular component | late endosome membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0097197 | Cellular component | tetraspanin-enriched microdomain |
GO_0019899 | Molecular function | enzyme binding |
GO_0005515 | Molecular function | protein binding |
Gene name | TSPAN15 |
Protein name | Tetraspanin 15 Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15) |
Synonyms | TM4SF15 NET7 UNQ677/PRO1311 |
Description | FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates . Promotes ADAM10-mediated cleavage of CDH2 . Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity . . |
Accessions | H7C285 ENST00000373290.7 O95858 ENST00000452130.1 |