TSPAN15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TSPAN15 at tissue level.

III. Associated gene sets

GO_0008593Biological processregulation of Notch signaling pathway
GO_0072659Biological processprotein localization to plasma membrane
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0051043Biological processregulation of membrane protein ectodomain proteolysis
GO_0051604Biological processprotein maturation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0009986Cellular componentcell surface
GO_0030054Cellular componentcell junction
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0016604Cellular componentnuclear body
GO_0031902Cellular componentlate endosome membrane
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0097197Cellular componenttetraspanin-enriched microdomain
GO_0019899Molecular functionenzyme binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTSPAN15
Protein nameTetraspanin 15
Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15)
SynonymsTM4SF15
NET7
UNQ677/PRO1311
DescriptionFUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates . Promotes ADAM10-mediated cleavage of CDH2 . Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity . .

AccessionsH7C285
ENST00000373290.7
O95858
ENST00000452130.1