TRIP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990116Biological processribosome-associated ubiquitin-dependent protein catabolic process
GO_0072344Biological processrescue of stalled ribosome
GO_0032790Biological processribosome disassembly
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045661Biological processregulation of myoblast differentiation
GO_0030520Biological processestrogen receptor signaling pathway
GO_0031594Cellular componentneuromuscular junction
GO_0005813Cellular componentcentrosome
GO_0180022Cellular componentRQC-trigger complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0099053Cellular componentactivating signal cointegrator 1 complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0016922Molecular functionnuclear receptor binding
GO_0019901Molecular functionprotein kinase binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0002020Molecular functionprotease binding
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0008270Molecular functionzinc ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0044389Molecular functionubiquitin-like protein ligase binding

IV. Literature review

[source]
Gene nameTRIP4
Protein nameActivating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4)
Thyroid hormone receptor interactor 4
SynonymsRQT4
DescriptionFUNCTION: Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription . May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions . Plays a role in thyroid hormone receptor and estrogen receptor transactivation . Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 . Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B . May play a role in the development of neuromuscular junction . May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation . .

AccessionsENST00000558162.1
ENST00000560567.5
ENST00000560920.6
H3BMU9
ENST00000558820.5
H0YLN7
Q15650
ENST00000560475.1
ENST00000261884.8
H0YK63
H0YKD9
H0YL91