TRIM68 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM68 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM68 at tissue level.

III. Associated gene sets

GO_0000209Biological processprotein polyubiquitination
GO_0045087Biological processinnate immune response
GO_0032880Biological processregulation of protein localization
GO_0051865Biological processprotein autoubiquitination
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0010508Biological processpositive regulation of autophagy
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0046596Biological processregulation of viral entry into host cell
GO_0005730Cellular componentnucleolus
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0008270Molecular functionzinc ion binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM68
Protein nameTripartite motif containing 68
E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68)
SynonymsSS56
GC109
RNF137
DescriptionFUNCTION: Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. .

AccessionsENST00000533021.1
ENST00000531101.5
ENST00000526337.5
E9PR29
E9PJJ9
Q6AZZ1
E9PP83
ENST00000300747.10 [Q6AZZ1-1]