TRIM59 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte	9 studies	40% ± 21%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	27% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	99%	331.01	961 / 966	98%	4.34	517 / 527
esophagus	97%	338.35	1407 / 1445	100%	7.47	183 / 183
lung	98%	242.62	567 / 578	99%	6.03	1140 / 1155
uterus	96%	237.50	163 / 170	98%	7.99	450 / 459
prostate	98%	242.42	239 / 245	92%	2.25	464 / 502
thymus	98%	193.40	640 / 653	92%	3.29	556 / 605
stomach	90%	181.53	323 / 359	98%	4.45	280 / 286
ovary	90%	160.90	162 / 180	98%	6.18	420 / 430
bladder	86%	206.71	18 / 21	98%	4.83	494 / 504
pancreas	69%	92.56	227 / 328	97%	4.04	172 / 178
breast	65%	97.25	297 / 459	100%	6.14	1113 / 1118
skin	100%	702.77	1800 / 1809	59%	1.42	280 / 472
kidney	73%	135.43	65 / 89	81%	2.15	726 / 901
brain	90%	489.40	2373 / 2642	60%	1.77	426 / 705
adrenal gland	64%	76.16	164 / 258	66%	1.42	151 / 230
lymph node	0%	0	0 / 0	100%	7.04	29 / 29
spleen	100%	658.54	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	10.56	45 / 45
ureter	0%	0	0 / 0	100%	1.54	1 / 1
blood vessel	85%	206.36	1138 / 1335	0%	0	0 / 0
peripheral blood	68%	549.35	636 / 929	0%	0	0 / 0
adipose	49%	64.24	587 / 1204	0%	0	0 / 0
liver	15%	17.10	35 / 226	33%	0.78	132 / 406
eye	0%	0	0 / 0	15%	0.18	12 / 80
heart	11%	12.58	93 / 861	0%	0	0 / 0
muscle	2%	1.80	15 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0016567	Biological process	protein ubiquitination
GO_0046597	Biological process	negative regulation of viral entry into host cell
GO_0043124	Biological process	negative regulation of canonical NF-kappaB signal transduction
GO_0045087	Biological process	innate immune response
GO_0005783	Cellular component	endoplasmic reticulum
GO_0030992	Cellular component	intraciliary transport particle B
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

Gene name	TRIM59
Protein name	Tripartite motif containing 59 Tripartite motif-containing protein 59 (EC 2.3.2.27) (RING finger protein 104) (Tumor suppressor TSBF-1)
Synonyms	TRIM57 RNF104 TSBF1
Description	FUNCTION: E3 ubiquitin ligase involved in different processes such as development and immune response . Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT . Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 . On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation . Acts also as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination (By similarity). .
Accessions	ENST00000496222.1 ENST00000543469.1 ENST00000471155.5 C9IZE0 ENST00000468542.1 ENST00000309784.9 [Q8IWR1-1] C9JNB9 C9J9F0 C9IY67 ENST00000494486.1 F5GZP3 C9JE08 Q8IWR1 ENST00000471396.1 C9J614 ENST00000479460.5

TRIM59 report