TRIM58 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM58 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	611.44	651 / 653	89%	15.59	539 / 605
prostate	56%	69.51	137 / 245	73%	4.27	365 / 502
breast	47%	30.85	214 / 459	56%	6.57	621 / 1118
lung	89%	166.59	515 / 578	7%	0.75	79 / 1155
spleen	96%	372.75	231 / 241	0%	0	0 / 0
ovary	2%	1.11	3 / 180	83%	11.52	359 / 430
intestine	64%	62.57	618 / 966	20%	1.14	106 / 527
peripheral blood	81%	1682.65	757 / 929	0%	0	0 / 0
brain	47%	50.43	1240 / 2642	6%	0.20	40 / 705
skin	16%	13.39	296 / 1809	34%	4.42	160 / 472
adipose	43%	32.19	513 / 1204	0%	0	0 / 0
uterus	14%	9.49	23 / 170	20%	1.37	90 / 459
eye	0%	0	0 / 0	31%	1.17	25 / 80
stomach	18%	13.32	64 / 359	13%	0.79	37 / 286
kidney	19%	16.24	17 / 89	7%	0.45	64 / 901
bladder	14%	8.86	3 / 21	10%	0.79	52 / 504
esophagus	17%	11.89	240 / 1445	7%	0.39	12 / 183
adrenal gland	5%	5.33	13 / 258	11%	0.67	26 / 230
liver	12%	11.64	28 / 226	1%	0.03	3 / 406
heart	12%	12.81	104 / 861	0%	0	0 / 0
blood vessel	8%	6.91	110 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	4%	0.13	2 / 45
pancreas	1%	1.43	4 / 328	2%	0.17	3 / 178
muscle	0%	0.30	4 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0000209	Biological process	protein polyubiquitination
GO_0045087	Biological process	innate immune response
GO_0032880	Biological process	regulation of protein localization
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0051865	Biological process	protein autoubiquitination
GO_1902838	Biological process	regulation of nuclear migration along microtubule
GO_0008150	Biological process	biological_process
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0010508	Biological process	positive regulation of autophagy
GO_0061931	Biological process	positive regulation of erythrocyte enucleation
GO_0046596	Biological process	regulation of viral entry into host cell
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0019901	Molecular function	protein kinase binding
GO_0008270	Molecular function	zinc ion binding
GO_0045505	Molecular function	dynein intermediate chain binding
GO_0045504	Molecular function	dynein heavy chain binding
GO_0003674	Molecular function	molecular_function

Gene name	TRIM58
Protein name	E3 ubiquitin-protein ligase TRIM58 (EC 2.3.2.27) (Protein BIA2) (RING-type E3 ubiquitin transferase TRIM58) (Tripartite motif-containing protein 58)
Synonyms
Description	FUNCTION: E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. .
Accessions	Q8NG06 ENST00000366481.4

TRIM58 report