Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 29% ± 11% | |
| endothelial cell | 4 studies | 22% ± 4% | |
| secretory cell | 4 studies | 20% ± 5% | |
| glutamatergic neuron | 4 studies | 26% ± 8% | |
| squamous epithelial cell | 3 studies | 40% ± 22% | |
| ciliated cell | 3 studies | 18% ± 3% | |
| GABAergic neuron | 3 studies | 26% ± 6% | |
| basal cell | 3 studies | 28% ± 7% | |
| goblet cell | 3 studies | 22% ± 5% | |
| astrocyte | 3 studies | 23% ± 2% | |
| interneuron | 3 studies | 26% ± 10% | |
| oligodendrocyte precursor cell | 3 studies | 26% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 22% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 5473.84 | 1442 / 1445 | 98% | 23.57 | 180 / 183 |
| bladder | 100% | 2438.33 | 21 / 21 | 97% | 18.60 | 490 / 504 |
| intestine | 100% | 1234.71 | 962 / 966 | 97% | 11.88 | 512 / 527 |
| lung | 99% | 1454.60 | 571 / 578 | 96% | 18.02 | 1113 / 1155 |
| stomach | 96% | 1602.45 | 346 / 359 | 96% | 10.04 | 275 / 286 |
| breast | 100% | 1340.73 | 459 / 459 | 92% | 7.19 | 1030 / 1118 |
| thymus | 100% | 1961.32 | 652 / 653 | 86% | 5.74 | 520 / 605 |
| brain | 86% | 620.31 | 2272 / 2642 | 98% | 6.87 | 691 / 705 |
| uterus | 82% | 629.63 | 139 / 170 | 98% | 22.65 | 450 / 459 |
| skin | 100% | 3510.32 | 1809 / 1809 | 73% | 4.53 | 344 / 472 |
| ovary | 88% | 544.38 | 158 / 180 | 74% | 4.13 | 318 / 430 |
| kidney | 85% | 662.87 | 76 / 89 | 74% | 4.70 | 665 / 901 |
| prostate | 92% | 974.20 | 225 / 245 | 60% | 2.61 | 300 / 502 |
| adrenal gland | 99% | 3017.28 | 256 / 258 | 48% | 4.12 | 110 / 230 |
| pancreas | 34% | 174.12 | 110 / 328 | 94% | 15.07 | 168 / 178 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.09 | 1 / 1 |
| adipose | 100% | 1683.17 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 98% | 1114.67 | 787 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 28.23 | 44 / 45 |
| heart | 95% | 1099.73 | 815 / 861 | 0% | 0 | 0 / 0 |
| spleen | 93% | 567.70 | 223 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 93% | 5.55 | 74 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 5.83 | 26 / 29 |
| blood vessel | 88% | 707.99 | 1169 / 1335 | 0% | 0 | 0 / 0 |
| liver | 19% | 110.63 | 42 / 226 | 49% | 7.41 | 198 / 406 |
| peripheral blood | 22% | 204.78 | 205 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032526 | Biological process | response to retinoic acid |
| GO_0032731 | Biological process | positive regulation of interleukin-1 beta production |
| GO_0060416 | Biological process | response to growth hormone |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0048386 | Biological process | positive regulation of retinoic acid receptor signaling pathway |
| GO_0045618 | Biological process | positive regulation of keratinocyte differentiation |
| GO_0046683 | Biological process | response to organophosphorus |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016605 | Cellular component | PML body |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0032089 | Molecular function | NACHT domain binding |
| GO_0003677 | Molecular function | DNA binding |
| GO_0016740 | Molecular function | transferase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0019966 | Molecular function | interleukin-1 binding |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | TRIM16 |
| Protein name | Tripartite motif containing 16 Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) Tripartite motif containing 16 (cDNA FLJ31464 fis, clone NT2NE2001337, highly similar to Tripartite motif-containing protein 16) |
| Synonyms | EBBP |
| Description | FUNCTION: E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. . |
| Accessions | ENST00000577372.5 ENST00000581200.1 J3QKY5 ENST00000579219.5 K7EJH2 ENST00000416464.6 B3KP96 ENST00000578237.5 [O95361-1] ENST00000578744.5 O95361 J3QR69 ENST00000649191.2 [O95361-1] ENST00000577446.5 ENST00000580110.5 K7ENN8 ENST00000336708.11 [O95361-1] J3QLP0 ENST00000494759.1 K7EL43 ENST00000577886.5 [O95361-2] J3QL38 |