TRIM16 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032526Biological processresponse to retinoic acid
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0060416Biological processresponse to growth hormone
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0048386Biological processpositive regulation of retinoic acid receptor signaling pathway
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0046683Biological processresponse to organophosphorus
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0032089Molecular functionNACHT domain binding
GO_0003677Molecular functionDNA binding
GO_0016740Molecular functiontransferase activity
GO_0005515Molecular functionprotein binding
GO_0019966Molecular functioninterleukin-1 binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM16
Protein nameTripartite motif containing 16
Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein)
Tripartite motif containing 16 (cDNA FLJ31464 fis, clone NT2NE2001337, highly similar to Tripartite motif-containing protein 16)
SynonymsEBBP
DescriptionFUNCTION: E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. .

AccessionsENST00000577372.5
ENST00000581200.1
J3QKY5
ENST00000579219.5
K7EJH2
ENST00000416464.6
B3KP96
ENST00000578237.5 [O95361-1]
ENST00000578744.5
O95361
J3QR69
ENST00000649191.2 [O95361-1]
ENST00000577446.5
ENST00000580110.5
K7ENN8
ENST00000336708.11 [O95361-1]
J3QLP0
ENST00000494759.1
K7EL43
ENST00000577886.5 [O95361-2]
J3QL38