TRIM11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM11 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0010468Biological processregulation of gene expression
GO_0045087Biological processinnate immune response
GO_0051865Biological processprotein autoubiquitination
GO_0046598Biological processpositive regulation of viral entry into host cell
GO_0050768Biological processnegative regulation of neurogenesis
GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0044790Biological processsuppression of viral release by host
GO_0140972Biological processnegative regulation of AIM2 inflammasome complex assembly
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0032897Biological processnegative regulation of viral transcription
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019904Molecular functionprotein domain specific binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM11
Protein nameTripartite motif containing 11
E3 ubiquitin-protein ligase TRIM11 (EC 2.3.2.27) (Protein BIA1) (RING finger protein 92) (Tripartite motif-containing protein 11)
SynonymsRNF92
DescriptionFUNCTION: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (By similarity). Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (By similarity). May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (By similarity). May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity). Mediates MED15 ubiquitination leading to proteasomal degradation . May contribute to the innate restriction of retroviruses . Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression . Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain . May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle . Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 . Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes . .

AccessionsENST00000284551.11 [Q96F44-1]
ENST00000366699.3 [Q96F44-2]
R4GNB9
R4GMV1
ENST00000493030.6
Q96F44
ENST00000602308.1
ENST00000602582.5
R4GNC3