I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 8 studies | 53% ± 17% | |
| cardiac muscle cell | 7 studies | 72% ± 24% | |
| Mueller cell | 5 studies | 82% ± 7% | |
| smooth muscle cell | 3 studies | 34% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 8 studies | 53% ± 17% | |
| cardiac muscle cell | 7 studies | 72% ± 24% | |
| Mueller cell | 5 studies | 82% ± 7% | |
| smooth muscle cell | 3 studies | 34% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| muscle | 100% | 83306.09 | 803 / 803 | 0% | 0 | 0 / 0 |
| heart | 100% | 12598.01 | 860 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 43% | 546.08 | 568 / 1335 | 0% | 0 | 0 / 0 |
| brain | 10% | 101.45 | 273 / 2642 | 12% | 0.40 | 88 / 705 |
| prostate | 9% | 451.35 | 22 / 245 | 8% | 1.61 | 41 / 502 |
| ovary | 6% | 101.86 | 11 / 180 | 10% | 0.25 | 43 / 430 |
| uterus | 8% | 82.89 | 13 / 170 | 7% | 0.74 | 32 / 459 |
| breast | 11% | 120.56 | 52 / 459 | 3% | 0.16 | 31 / 1118 |
| adipose | 14% | 135.00 | 163 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 1.40 | 5 / 45 |
| lung | 1% | 25.38 | 3 / 578 | 10% | 0.30 | 120 / 1155 |
| esophagus | 1% | 36.83 | 15 / 1445 | 8% | 0.22 | 15 / 183 |
| adrenal gland | 1% | 6.08 | 2 / 258 | 6% | 0.39 | 14 / 230 |
| thymus | 2% | 25.83 | 10 / 653 | 1% | 0.10 | 7 / 605 |
| skin | 1% | 31.23 | 13 / 1809 | 2% | 0.11 | 9 / 472 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.09 | 2 / 80 |
| kidney | 1% | 5.76 | 1 / 89 | 1% | 0.03 | 9 / 901 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.04 | 10 / 504 |
| stomach | 0% | 0 | 0 / 359 | 1% | 0.02 | 4 / 286 |
| peripheral blood | 1% | 19.68 | 12 / 929 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.10 | 4 / 406 |
| intestine | 1% | 4.74 | 7 / 966 | 0% | 0.01 | 1 / 527 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 0% | 0 | 0 / 178 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060315 | Biological process | negative regulation of ryanodine-sensitive calcium-release channel activity |
| GO_0031122 | Biological process | cytoplasmic microtubule organization |
| GO_0090158 | Biological process | endoplasmic reticulum membrane organization |
| GO_0009617 | Biological process | response to bacterium |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0006936 | Biological process | muscle contraction |
| GO_1901846 | Biological process | positive regulation of cell communication by electrical coupling involved in cardiac conduction |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0060316 | Biological process | positive regulation of ryanodine-sensitive calcium-release channel activity |
| GO_0060047 | Biological process | heart contraction |
| GO_0010649 | Biological process | regulation of cell communication by electrical coupling |
| GO_0051279 | Biological process | regulation of release of sequestered calcium ion into cytosol |
| GO_0010880 | Biological process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| GO_0086036 | Biological process | regulation of cardiac muscle cell membrane potential |
| GO_0014808 | Biological process | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0033018 | Cellular component | sarcoplasmic reticulum lumen |
| GO_0014701 | Cellular component | junctional sarcoplasmic reticulum membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0030314 | Cellular component | junctional membrane complex |
| GO_0016529 | Cellular component | sarcoplasmic reticulum |
| GO_0033017 | Cellular component | sarcoplasmic reticulum membrane |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
| GO_0044325 | Molecular function | transmembrane transporter binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TRDN |
| Protein name | Triadin |
| Synonyms | |
| Description | FUNCTION: Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. . |
| Accessions | H9ME53 ENST00000662930.1 H7BY47 ENST00000542443.5 [Q13061-3] Q13061 ENST00000546248.6 ENST00000334268.9 [Q13061-1] Q8IVK2 H0Y6P0 ENST00000628709.2 [Q13061-2] ENST00000361029.9 ENST00000422596.2 Q6PG49 A0A590UJV0 Q05C44 |
