TRAF3IP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0001822Biological processkidney development
GO_0032480Biological processnegative regulation of type I interferon production
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0050687Biological processnegative regulation of defense response to virus
GO_0001738Biological processmorphogenesis of a polarized epithelium
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0035720Biological processintraciliary anterograde transport
GO_0042073Biological processintraciliary transport
GO_0005813Cellular componentcentrosome
GO_0030992Cellular componentintraciliary transport particle B
GO_0005930Cellular componentaxoneme
GO_0097542Cellular componentciliary tip
GO_0005929Cellular componentcilium
GO_0035869Cellular componentciliary transition zone
GO_0097546Cellular componentciliary base
GO_0036064Cellular componentciliary basal body
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRAF3IP1
Protein nameTRAF3-interacting protein 1 (Interleukin-13 receptor alpha 1-binding protein 1) (Intraflagellar transport protein 54 homolog) (Microtubule-interacting protein associated with TRAF3) (MIP-T3)
TRAF3 interacting protein 1
SynonymsMIPT3
IFT54
DescriptionFUNCTION: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels . Involved in ciliogenesis (By similarity). .

AccessionsH7BZ10
Q8TDR0
ENST00000391993.7 [Q8TDR0-2]
ENST00000373327.5 [Q8TDR0-1]
ENST00000409739.2