Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 16 studies | 40% ± 21% | |
macrophage | 11 studies | 35% ± 16% | |
microglial cell | 10 studies | 31% ± 12% | |
fibroblast | 10 studies | 26% ± 12% | |
endothelial cell | 9 studies | 27% ± 10% | |
oligodendrocyte | 9 studies | 25% ± 9% | |
myeloid cell | 7 studies | 25% ± 7% | |
adipocyte | 6 studies | 22% ± 6% | |
epithelial cell | 5 studies | 34% ± 24% | |
mast cell | 5 studies | 25% ± 5% | |
cardiac muscle cell | 4 studies | 32% ± 2% | |
ciliated cell | 4 studies | 22% ± 6% | |
oligodendrocyte precursor cell | 4 studies | 29% ± 7% | |
smooth muscle cell | 4 studies | 29% ± 8% | |
respiratory goblet cell | 4 studies | 30% ± 11% | |
endothelial cell of lymphatic vessel | 4 studies | 28% ± 5% | |
goblet cell | 4 studies | 30% ± 15% | |
hepatocyte | 3 studies | 35% ± 13% | |
GABAergic neuron | 3 studies | 38% ± 11% | |
glutamatergic neuron | 3 studies | 45% ± 12% | |
granule cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 12481.78 | 258 / 258 | 100% | 38.19 | 230 / 230 |
intestine | 100% | 7474.15 | 966 / 966 | 100% | 28.70 | 526 / 527 |
thymus | 100% | 16289.51 | 653 / 653 | 100% | 55.28 | 603 / 605 |
kidney | 100% | 11108.01 | 89 / 89 | 99% | 39.36 | 896 / 901 |
skin | 100% | 5452.44 | 1808 / 1809 | 99% | 30.86 | 469 / 472 |
prostate | 100% | 8119.50 | 245 / 245 | 99% | 17.84 | 497 / 502 |
brain | 99% | 8306.00 | 2614 / 2642 | 100% | 34.64 | 705 / 705 |
breast | 100% | 8319.62 | 459 / 459 | 98% | 26.18 | 1101 / 1118 |
pancreas | 100% | 7713.82 | 328 / 328 | 98% | 28.53 | 175 / 178 |
bladder | 100% | 6732.57 | 21 / 21 | 98% | 22.85 | 493 / 504 |
esophagus | 100% | 7630.73 | 1444 / 1445 | 98% | 25.15 | 179 / 183 |
ovary | 100% | 10498.44 | 180 / 180 | 97% | 26.71 | 419 / 430 |
lung | 100% | 8070.45 | 577 / 578 | 98% | 24.77 | 1127 / 1155 |
uterus | 100% | 9385.69 | 170 / 170 | 96% | 17.26 | 441 / 459 |
stomach | 97% | 4180.11 | 347 / 359 | 99% | 26.94 | 284 / 286 |
liver | 97% | 3765.78 | 219 / 226 | 94% | 19.42 | 381 / 406 |
eye | 0% | 0 | 0 / 0 | 100% | 27.71 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 26.90 | 29 / 29 |
spleen | 100% | 7625.12 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.92 | 1 / 1 |
blood vessel | 100% | 9136.87 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 7031.28 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 100% | 9334.18 | 860 / 861 | 0% | 0 | 0 / 0 |
muscle | 97% | 4574.74 | 781 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 15.69 | 43 / 45 |
peripheral blood | 48% | 2167.06 | 450 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0019722 | Biological process | calcium-mediated signaling |
GO_0034220 | Biological process | monoatomic ion transmembrane transport |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_0075509 | Biological process | endocytosis involved in viral entry into host cell |
GO_0035725 | Biological process | sodium ion transmembrane transport |
GO_0070588 | Biological process | calcium ion transmembrane transport |
GO_0034702 | Cellular component | monoatomic ion channel complex |
GO_0031901 | Cellular component | early endosome membrane |
GO_0005764 | Cellular component | lysosome |
GO_0055038 | Cellular component | recycling endosome membrane |
GO_0036019 | Cellular component | endolysosome |
GO_0010008 | Cellular component | endosome membrane |
GO_0005768 | Cellular component | endosome |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0097682 | Molecular function | intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity |
GO_0072345 | Molecular function | NAADP-sensitive calcium-release channel activity |
GO_0005248 | Molecular function | voltage-gated sodium channel activity |
GO_0015280 | Molecular function | ligand-gated sodium channel activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0022832 | Molecular function | voltage-gated channel activity |
GO_0080025 | Molecular function | phosphatidylinositol-3,5-bisphosphate binding |
GO_0005515 | Molecular function | protein binding |
GO_0019905 | Molecular function | syntaxin binding |
Gene name | TPCN1 |
Protein name | Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1) Two pore segment channel 1 TPCN1 protein |
Synonyms | KIAA1169 TPC1 |
Description | FUNCTION: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles . Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable). .; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. . |
Accessions | F8VVY9 F8VZZ6 F8W0K7 ENST00000552542.5 ENST00000551099.5 A5PKY2 ENST00000546781.5 ENST00000550785.5 [Q9ULQ1-3] ENST00000541517.5 [Q9ULQ1-3] H0YHX1 F8VR74 F8VS97 F8VV93 ENST00000552985.5 ENST00000549279.1 F8W1L6 ENST00000550873.5 H0YIK4 ENST00000392569.8 ENST00000547275.5 F8W0P9 ENST00000547955.5 ENST00000551096.5 ENST00000552642.5 Q9ULQ1 B7Z3R2 ENST00000335509.11 [Q9ULQ1-1] ENST00000552897.5 ENST00000548465.1 F8W1G4 |