TPCN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019722Biological processcalcium-mediated signaling
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0010508Biological processpositive regulation of autophagy
GO_0075509Biological processendocytosis involved in viral entry into host cell
GO_0035725Biological processsodium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0034702Cellular componentmonoatomic ion channel complex
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0036019Cellular componentendolysosome
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0097682Molecular functionintracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
GO_0072345Molecular functionNAADP-sensitive calcium-release channel activity
GO_0005248Molecular functionvoltage-gated sodium channel activity
GO_0015280Molecular functionligand-gated sodium channel activity
GO_0042802Molecular functionidentical protein binding
GO_0022832Molecular functionvoltage-gated channel activity
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0005515Molecular functionprotein binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameTPCN1
Protein nameTwo pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1)
Two pore segment channel 1
TPCN1 protein
SynonymsKIAA1169
TPC1
DescriptionFUNCTION: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles . Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable). .; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. .

AccessionsF8VVY9
F8VZZ6
F8W0K7
ENST00000552542.5
ENST00000551099.5
A5PKY2
ENST00000546781.5
ENST00000550785.5 [Q9ULQ1-3]
ENST00000541517.5 [Q9ULQ1-3]
H0YHX1
F8VR74
F8VS97
F8VV93
ENST00000552985.5
ENST00000549279.1
F8W1L6
ENST00000550873.5
H0YIK4
ENST00000392569.8
ENST00000547275.5
F8W0P9
ENST00000547955.5
ENST00000551096.5
ENST00000552642.5
Q9ULQ1
B7Z3R2
ENST00000335509.11 [Q9ULQ1-1]
ENST00000552897.5
ENST00000548465.1
F8W1G4