TNPO3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006606Biological processprotein import into nucleus
GO_0005642Cellular componentannulate lamellae
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005635Cellular componentnuclear envelope
GO_0005737Cellular componentcytoplasm
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0061608Molecular functionnuclear import signal receptor activity

IV. Literature review

[source]
Gene nameTNPO3
Protein nameTransportin 3
Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)
SynonymsIPO12
DescriptionFUNCTION: Importin, which transports target proteins into the nucleus . Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains . Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation . The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively . Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus . .; FUNCTION: (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus . Required for a nuclear maturation step of HIV-1 prior to integration . .

AccessionsE9PFH4
C9J7E5
ENST00000471234.5 [Q9Y5L0-5]
ENST00000471166.1
ENST00000627585.2
Q9Y5L0
ENST00000482320.5
ENST00000265388.10 [Q9Y5L0-2]