Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 25 studies | 30% ± 12% | |
CD16-negative, CD56-bright natural killer cell, human | 11 studies | 30% ± 9% | |
CD16-positive, CD56-dim natural killer cell, human | 11 studies | 26% ± 9% | |
plasmacytoid dendritic cell | 11 studies | 30% ± 8% | |
CD4-positive, alpha-beta T cell | 8 studies | 28% ± 15% | |
mucosal invariant T cell | 7 studies | 23% ± 6% | |
mature NK T cell | 6 studies | 36% ± 17% | |
gamma-delta T cell | 6 studies | 44% ± 14% | |
innate lymphoid cell | 6 studies | 32% ± 12% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 5 studies | 21% ± 7% | |
CD8-positive, alpha-beta T cell | 5 studies | 42% ± 11% | |
group 3 innate lymphoid cell | 5 studies | 65% ± 12% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 4 studies | 25% ± 8% | |
intraepithelial lymphocyte | 3 studies | 42% ± 14% | |
T cell | 3 studies | 35% ± 10% |
Insufficient scRNA-seq data for expression of TMIGD2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 84% | 38.74 | 2209 / 2642 | 92% | 5.79 | 647 / 705 |
lung | 96% | 50.56 | 554 / 578 | 47% | 1.14 | 538 / 1155 |
intestine | 59% | 71.61 | 573 / 966 | 59% | 1.49 | 313 / 527 |
bladder | 57% | 27.10 | 12 / 21 | 61% | 1.93 | 309 / 504 |
stomach | 58% | 18.46 | 210 / 359 | 51% | 1.37 | 147 / 286 |
spleen | 100% | 329.69 | 241 / 241 | 0% | 0 | 0 / 0 |
liver | 77% | 19.65 | 175 / 226 | 18% | 0.47 | 74 / 406 |
lymph node | 0% | 0 | 0 / 0 | 90% | 6.14 | 26 / 29 |
peripheral blood | 88% | 405.12 | 816 / 929 | 0% | 0 | 0 / 0 |
uterus | 28% | 6.23 | 47 / 170 | 56% | 2.34 | 255 / 459 |
tonsil | 0% | 0 | 0 / 0 | 78% | 3.24 | 35 / 45 |
prostate | 56% | 14.61 | 138 / 245 | 15% | 0.31 | 77 / 502 |
pancreas | 7% | 1.27 | 23 / 328 | 64% | 1.73 | 114 / 178 |
kidney | 27% | 8.36 | 24 / 89 | 44% | 0.90 | 397 / 901 |
thymus | 41% | 9.39 | 265 / 653 | 26% | 21.01 | 160 / 605 |
breast | 42% | 7.38 | 193 / 459 | 22% | 0.55 | 241 / 1118 |
esophagus | 28% | 9.02 | 401 / 1445 | 35% | 0.88 | 64 / 183 |
adipose | 55% | 10.88 | 660 / 1204 | 0% | 0 | 0 / 0 |
adrenal gland | 13% | 1.81 | 34 / 258 | 27% | 1.38 | 62 / 230 |
skin | 7% | 1.19 | 132 / 1809 | 23% | 0.91 | 110 / 472 |
ovary | 7% | 1.08 | 12 / 180 | 22% | 0.50 | 95 / 430 |
blood vessel | 25% | 5.50 | 337 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 11% | 0.20 | 9 / 80 |
heart | 8% | 1.11 | 73 / 861 | 0% | 0 | 0 / 0 |
muscle | 1% | 0.13 | 9 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0031295 | Biological process | T cell costimulation |
GO_0042104 | Biological process | positive regulation of activated T cell proliferation |
GO_0050853 | Biological process | B cell receptor signaling pathway |
GO_0001819 | Biological process | positive regulation of cytokine production |
GO_0045766 | Biological process | positive regulation of angiogenesis |
GO_0019815 | Cellular component | B cell receptor complex |
GO_0015026 | Molecular function | coreceptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TMIGD2 |
Protein name | Transmembrane and immunoglobulin domain containing 2 Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1) |
Synonyms | IGPR1 CD28H UNQ3059/PRO9879 |
Description | FUNCTION: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. . |
Accessions | ENST00000301272.6 [Q96BF3-1] A0A0B4J2B0 A0A0B4J2A9 Q96BF3 ENST00000595645.6 [Q96BF3-2] ENST00000600349.1 ENST00000600114.5 |