TMIGD2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TMIGD2 at tissue level.

III. Associated gene sets

GO_0031295Biological processT cell costimulation
GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_0050853Biological processB cell receptor signaling pathway
GO_0001819Biological processpositive regulation of cytokine production
GO_0045766Biological processpositive regulation of angiogenesis
GO_0019815Cellular componentB cell receptor complex
GO_0015026Molecular functioncoreceptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMIGD2
Protein nameTransmembrane and immunoglobulin domain containing 2
Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)
SynonymsIGPR1
CD28H
UNQ3059/PRO9879
DescriptionFUNCTION: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. .

AccessionsENST00000301272.6 [Q96BF3-1]
A0A0B4J2B0
A0A0B4J2A9
Q96BF3
ENST00000595645.6 [Q96BF3-2]
ENST00000600349.1
ENST00000600114.5