TMEM97 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140077Biological processpositive regulation of lipoprotein transport
GO_0032377Biological processregulation of intracellular lipid transport
GO_0001558Biological processregulation of cell growth
GO_0032383Biological processregulation of intracellular cholesterol transport
GO_0042632Biological processcholesterol homeostasis
GO_0090303Biological processpositive regulation of wound healing
GO_0005764Cellular componentlysosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0031965Cellular componentnuclear membrane
GO_0005886Cellular componentplasma membrane
GO_0030867Cellular componentrough endoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0015485Molecular functioncholesterol binding
GO_0008142Molecular functionoxysterol binding

IV. Literature review

[source]
Gene nameTMEM97
Protein nameTMEM97 protein (Transmembrane protein 97)
Transmembrane protein 97
Sigma intracellular receptor 2 (S2R) (Sigma-2 receptor) (Sigma2 receptor) (Meningioma-associated protein 30) (MAC30) (Transmembrane protein 97)
SynonymsMAC30
S2R
DescriptionFUNCTION: Sigma-2 receptor which contributes to ameliorate dysfunctional cellular processes and slow degenerative progression by regulating cell functions including cholesterol biosynthesis/trafficking, membrane trafficking, autophagy, lipid membrane-bound protein trafficking, and receptor stabilization at the cell surface (Probable). Forms a ternary complex with PGRMC1 receptor and low density lipoprotein receptor/LDLR at the plasma membrane, which increases LDLR-mediated LDL cholesterol internalization . Decreases lysosomal sterol transporter NPC1 availability to the cell, probably through NPC1-binding, hence controlling lipid transport, including cholesterol and LBPA, outside of late endosome/lysosome . Binds regio- and stereoselective ligand 20(S)-hydroxycholesterol (20(S)-OHC) which enhances TMEM97-NPC1 interaction and decreases TMEM97-PGRMC1 and TMEM97-TSPO interactions, thereby linking OHC binding to cholesterol homeostasis . Also able to bind cholesterol (By similarity). Binds histatin 1 (Hst 1)/HN1 salivary peptide at the ER membrane, which is critical for increasing mitochondria-ER contacts and stimulating Hst1 wound healing properties . May alter the activity of some cytochrome P450 proteins . Although shows homologies with sterol isomerases (EXPERA domain), not able to catalyze sterol isomerization (Probable) . However, may act as sensors of these molecules (Probable) . Acts as a quality control factor in the ER, promoting the proteolytic degradation of nonproductive and extramitochondrial precursor proteins in the ER membrane thus removing them from the ER surface (By similarity). .

AccessionsENST00000336687.6
ENST00000583381.5
ENST00000582113.1
ENST00000582384.1
ENST00000226230.8
J3KT68
Q86XC5
J3KTD1
Q5BJF2