TMEM65 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0003231Biological processcardiac ventricle development
GO_1903779Biological processregulation of cardiac conduction
GO_0061337Biological processcardiac conduction
GO_0005886Cellular componentplasma membrane
GO_0014704Cellular componentintercalated disc
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMEM65
Protein nameTransmembrane protein 65
Synonyms
DescriptionFUNCTION: Essential for maintaining proper cardiac intercalated disk (ICD) structure and function as well as cardiac conduction velocity in the heart. Its association with SCN1B is required for stabilizing the perinexus in the ICD and for localization of GJA1 and SCN5A to the ICD. May regulate the function of the gap junction protein GJA1 and may contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance . .

AccessionsENST00000297632.8
A0A994J4W9
ENST00000704783.1
A0A994J4P3
Q6PI78
ENST00000704788.1
A0A994J7M8
ENST00000704786.1
ENST00000704785.1
A0A994J794