TMEM33 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071786Biological processendoplasmic reticulum tubular network organization
GO_0061024Biological processmembrane organization
GO_1903371Biological processregulation of endoplasmic reticulum tubular network organization
GO_1903899Biological processpositive regulation of PERK-mediated unfolded protein response
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0045087Biological processinnate immune response
GO_1903896Biological processpositive regulation of IRE1-mediated unfolded protein response
GO_0005783Cellular componentendoplasmic reticulum
GO_0042470Cellular componentmelanosome
GO_0005635Cellular componentnuclear envelope
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMEM33
Protein nameTransmembrane protein 33 (Protein DB83) (SHINC-3)
Transmembrane protein 33
SynonymsDB83
DescriptionFUNCTION: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules . Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling . Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis . Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 . Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane . .

AccessionsENST00000513702.5
P57088
ENST00000506794.1
ENST00000513558.1
D6RAA6
ENST00000508448.5
J3KN43
ENST00000264452.9
D6RBY2
H0Y8N0
ENST00000504986.6