Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| classical monocyte | 8 studies | 23% ± 8% | |
| epithelial cell | 6 studies | 35% ± 14% | |
| non-classical monocyte | 5 studies | 22% ± 9% | |
| endothelial cell | 5 studies | 21% ± 5% | |
| neuron | 4 studies | 27% ± 12% | |
| ciliated cell | 4 studies | 29% ± 7% | |
| macrophage | 4 studies | 23% ± 4% | |
| GABAergic neuron | 4 studies | 35% ± 10% | |
| glutamatergic neuron | 4 studies | 42% ± 15% | |
| basal cell | 4 studies | 28% ± 10% | |
| oligodendrocyte | 4 studies | 22% ± 1% | |
| pancreatic A cell | 3 studies | 35% ± 18% | |
| conventional dendritic cell | 3 studies | 23% ± 8% | |
| myeloid cell | 3 studies | 29% ± 10% | |
| monocyte | 3 studies | 23% ± 4% | |
| dendritic cell | 3 studies | 28% ± 9% | |
| goblet cell | 3 studies | 20% ± 3% | |
| alveolar macrophage | 3 studies | 19% ± 3% | |
| astrocyte | 3 studies | 21% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2013.50 | 1445 / 1445 | 100% | 40.65 | 183 / 183 |
| lung | 100% | 2600.39 | 578 / 578 | 100% | 35.71 | 1155 / 1155 |
| ovary | 100% | 1807.13 | 180 / 180 | 100% | 24.13 | 430 / 430 |
| prostate | 100% | 2019.16 | 245 / 245 | 100% | 37.96 | 502 / 502 |
| breast | 100% | 2133.46 | 459 / 459 | 100% | 37.68 | 1117 / 1118 |
| brain | 100% | 2197.87 | 2639 / 2642 | 100% | 30.54 | 705 / 705 |
| stomach | 100% | 1810.38 | 359 / 359 | 100% | 36.51 | 285 / 286 |
| intestine | 100% | 1911.76 | 966 / 966 | 100% | 35.46 | 525 / 527 |
| skin | 100% | 2889.77 | 1809 / 1809 | 100% | 40.47 | 470 / 472 |
| liver | 100% | 3351.24 | 226 / 226 | 100% | 26.59 | 404 / 406 |
| bladder | 100% | 1773.19 | 21 / 21 | 99% | 30.47 | 501 / 504 |
| thymus | 100% | 2218.78 | 653 / 653 | 99% | 27.94 | 601 / 605 |
| kidney | 100% | 1966.18 | 89 / 89 | 99% | 27.72 | 893 / 901 |
| uterus | 100% | 1674.83 | 170 / 170 | 99% | 27.96 | 454 / 459 |
| adrenal gland | 100% | 2800.70 | 258 / 258 | 99% | 28.16 | 227 / 230 |
| pancreas | 100% | 1419.19 | 327 / 328 | 99% | 28.21 | 176 / 178 |
| adipose | 100% | 2081.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 18.60 | 29 / 29 |
| spleen | 100% | 2146.52 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 28.27 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.23 | 1 / 1 |
| blood vessel | 100% | 1522.47 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1179.80 | 795 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 2910.97 | 902 / 929 | 0% | 0 | 0 / 0 |
| heart | 96% | 1175.39 | 830 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 27.84 | 77 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071786 | Biological process | endoplasmic reticulum tubular network organization |
| GO_0061024 | Biological process | membrane organization |
| GO_1903371 | Biological process | regulation of endoplasmic reticulum tubular network organization |
| GO_1903899 | Biological process | positive regulation of PERK-mediated unfolded protein response |
| GO_0034976 | Biological process | response to endoplasmic reticulum stress |
| GO_0045087 | Biological process | innate immune response |
| GO_1903896 | Biological process | positive regulation of IRE1-mediated unfolded protein response |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0042470 | Cellular component | melanosome |
| GO_0005635 | Cellular component | nuclear envelope |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TMEM33 |
| Protein name | Transmembrane protein 33 (Protein DB83) (SHINC-3) Transmembrane protein 33 |
| Synonyms | DB83 |
| Description | FUNCTION: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules . Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling . Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis . Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 . Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane . . |
| Accessions | ENST00000513702.5 P57088 ENST00000506794.1 ENST00000513558.1 D6RAA6 ENST00000508448.5 J3KN43 ENST00000264452.9 D6RBY2 H0Y8N0 ENST00000504986.6 |