TLX2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TLX2 at tissue level.

III. Associated gene sets

GO_0050774Biological processnegative regulation of dendrite morphogenesis
GO_0001707Biological processmesoderm formation
GO_0048513Biological processanimal organ development
GO_0048484Biological processenteric nervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005575Cellular componentcellular_component
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding

IV. Literature review

[source]
Gene nameTLX2
Protein nameT-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein)
T cell leukemia homeobox 2 (T-cell leukemia homeobox protein 2)
SynonymsNCX
HOX11L1
DescriptionFUNCTION: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity). .

AccessionsENST00000233638.8
F1T0F2
ENST00000621092.1
O43763