TIPIN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008284Biological processpositive regulation of cell population proliferation
GO_0033262Biological processregulation of nuclear cell cycle DNA replication
GO_0031573Biological processmitotic intra-S DNA damage checkpoint signaling
GO_0031297Biological processreplication fork processing
GO_0009411Biological processresponse to UV
GO_0043111Biological processreplication fork arrest
GO_0044770Biological processcell cycle phase transition
GO_0051301Biological processcell division
GO_0000076Biological processDNA replication checkpoint signaling
GO_0031298Cellular componentreplication fork protection complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTIPIN
Protein nameTIMELESS interacting protein
TIMELESS-interacting protein
Synonyms
DescriptionFUNCTION: Plays an important role in the control of DNA replication and the maintenance of replication fork stability . Important for cell survival after DNA damage or replication stress . May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light . Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress . .

FUNCTION: Plays an important role in the control of DNA replication and the maintenance of replication fork stability. .

FUNCTION: Plays an important role in the control of DNA replication and the maintenance of replication fork stability. .

FUNCTION: Plays an important role in the control of DNA replication and the maintenance of replication fork stability. .

AccessionsQ9BVW5
H3BTH1
ENST00000568216.5
H3BVG9
H3BQ83
H3BU04
ENST00000566524.5
ENST00000570251.1
ENST00000562124.5
ENST00000261881.9