TFIP11 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TFIP11 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TFIP11 at tissue level.

III. Associated gene sets

GO_0031848Biological processprotection from non-homologous end joining at telomere
GO_0006396Biological processRNA processing
GO_2001033Biological processnegative regulation of double-strand break repair via nonhomologous end joining
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000390Biological processspliceosomal complex disassembly
GO_0031214Biological processbiomineral tissue development
GO_1904876Biological processnegative regulation of DNA ligase activity
GO_0032091Biological processnegative regulation of protein binding
GO_0005730Cellular componentnucleolus
GO_0005681Cellular componentspliceosomal complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0031012Cellular componentextracellular matrix
GO_0005737Cellular componentcytoplasm
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0000781Cellular componentchromosome, telomeric region
GO_0071008Cellular componentU2-type post-mRNA release spliceosomal complex
GO_0003676Molecular functionnucleic acid binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTFIP11
Protein nameTuftelin interacting protein 11
Tuftelin-interacting protein 11
Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1)
SynonymsCTA-445C9.9-015
HSPC006
STIP
DescriptionFUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. .

FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. .

AccessionsENST00000407690.6 [Q9UBB9-1]
F6UKU9
ENST00000420242.5
F6UQ07
ENST00000455080.5
ENST00000440258.1
ENST00000407148.5 [Q9UBB9-1]
ENST00000450493.1
F6XM96
H0Y4U8
ENST00000405938.5 [Q9UBB9-1]
Q8N523
ENST00000418876.5
F6SQZ1
B1AHQ3
Q9UBB9
ENST00000407431.5 [Q9UBB9-1]
ENST00000619735.4 [Q9UBB9-1]