TESK1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TESK1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TESK1 at tissue level.

III. Associated gene sets

GO_1902018Biological processnegative regulation of cilium assembly
GO_0007283Biological processspermatogenesis
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0032880Biological processregulation of protein localization
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0042326Biological processnegative regulation of phosphorylation
GO_0030036Biological processactin cytoskeleton organization
GO_0090521Biological processpodocyte cell migration
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0031953Biological processnegative regulation of protein autophosphorylation
GO_0051650Biological processestablishment of vesicle localization
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTESK1
Protein nameDual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1)
Synonyms
DescriptionFUNCTION: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin . Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 . Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). .

AccessionsENST00000336395.6
Q15569