Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| natural killer cell | 7 studies | 18% ± 4% | |
| glutamatergic neuron | 7 studies | 38% ± 24% | |
| macrophage | 7 studies | 25% ± 10% | |
| epithelial cell | 6 studies | 27% ± 12% | |
| endothelial cell | 5 studies | 25% ± 3% | |
| GABAergic neuron | 5 studies | 40% ± 20% | |
| microglial cell | 5 studies | 21% ± 6% | |
| monocyte | 4 studies | 18% ± 2% | |
| CD16-negative, CD56-bright natural killer cell, human | 4 studies | 19% ± 4% | |
| CD16-positive, CD56-dim natural killer cell, human | 4 studies | 25% ± 6% | |
| astrocyte | 4 studies | 28% ± 9% | |
| smooth muscle cell | 4 studies | 19% ± 4% | |
| interneuron | 4 studies | 38% ± 22% | |
| effector memory CD8-positive, alpha-beta T cell | 3 studies | 19% ± 4% | |
| myeloid cell | 3 studies | 19% ± 3% | |
| ciliated cell | 3 studies | 29% ± 8% | |
| oligodendrocyte precursor cell | 3 studies | 28% ± 7% | |
| dendritic cell | 3 studies | 27% ± 9% | |
| oligodendrocyte | 3 studies | 28% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 39% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1354.82 | 1445 / 1445 | 100% | 10.24 | 183 / 183 |
| prostate | 100% | 1406.00 | 245 / 245 | 100% | 8.66 | 502 / 502 |
| lung | 100% | 1343.40 | 577 / 578 | 100% | 7.86 | 1150 / 1155 |
| stomach | 100% | 1178.82 | 359 / 359 | 99% | 9.52 | 283 / 286 |
| breast | 100% | 1218.79 | 459 / 459 | 99% | 10.23 | 1106 / 1118 |
| intestine | 100% | 1538.28 | 966 / 966 | 99% | 9.09 | 520 / 527 |
| thymus | 100% | 1272.47 | 653 / 653 | 99% | 7.49 | 596 / 605 |
| brain | 99% | 1081.21 | 2618 / 2642 | 99% | 6.50 | 700 / 705 |
| kidney | 100% | 961.47 | 89 / 89 | 98% | 8.79 | 886 / 901 |
| adrenal gland | 100% | 1515.92 | 258 / 258 | 98% | 8.68 | 226 / 230 |
| uterus | 100% | 1917.29 | 170 / 170 | 98% | 6.65 | 451 / 459 |
| pancreas | 99% | 673.60 | 324 / 328 | 99% | 6.14 | 177 / 178 |
| bladder | 100% | 1792.62 | 21 / 21 | 98% | 7.03 | 495 / 504 |
| ovary | 100% | 1595.39 | 180 / 180 | 97% | 5.65 | 415 / 430 |
| liver | 100% | 1202.65 | 226 / 226 | 93% | 4.81 | 378 / 406 |
| skin | 100% | 1397.73 | 1807 / 1809 | 91% | 5.64 | 429 / 472 |
| adipose | 100% | 1453.71 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2175.68 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 7.97 | 29 / 29 |
| spleen | 100% | 1206.29 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.84 | 1 / 1 |
| muscle | 99% | 757.71 | 798 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 5.60 | 44 / 45 |
| heart | 97% | 616.75 | 836 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 80% | 945.14 | 740 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 65% | 3.26 | 52 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1905870 | Biological process | positive regulation of 3'-UTR-mediated mRNA stabilization |
| GO_0071076 | Biological process | RNA 3' uridylation |
| GO_0031124 | Biological process | mRNA 3'-end processing |
| GO_0071051 | Biological process | poly(A)-dependent snoRNA 3'-end processing |
| GO_0071044 | Biological process | histone mRNA catabolic process |
| GO_0051301 | Biological process | cell division |
| GO_0010587 | Biological process | miRNA catabolic process |
| GO_0032211 | Biological process | negative regulation of telomere maintenance via telomerase |
| GO_0033500 | Biological process | carbohydrate homeostasis |
| GO_0060212 | Biological process | negative regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| GO_0043634 | Biological process | polyadenylation-dependent ncRNA catabolic process |
| GO_0006364 | Biological process | rRNA processing |
| GO_0031123 | Biological process | RNA 3'-end processing |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031499 | Cellular component | TRAMP complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0070568 | Molecular function | guanylyltransferase activity |
| GO_1990817 | Molecular function | poly(A) RNA polymerase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0070034 | Molecular function | telomerase RNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TENT4B |
| Protein name | PAPD5 protein Terminal nucleotidyltransferase 4B Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) PAP associated domain containing 5 |
| Synonyms | TRF4-2 TUT3 GLD4 PAPD5 |
| Description | FUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation . Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) . Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 . Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion . Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation . Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation . . |
| Accessions | B7ZLC1 E9PC61 Q5EBM7 ENST00000357464.4 A0A7N4YH79 G4U4J3 ENST00000436909.8 [Q8NDF8-5] ENST00000561678.7 Q8NDF8 |