TENT4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905870Biological processpositive regulation of 3'-UTR-mediated mRNA stabilization
GO_0071076Biological processRNA 3' uridylation
GO_0031124Biological processmRNA 3'-end processing
GO_0071051Biological processpoly(A)-dependent snoRNA 3'-end processing
GO_0071044Biological processhistone mRNA catabolic process
GO_0051301Biological processcell division
GO_0010587Biological processmiRNA catabolic process
GO_0032211Biological processnegative regulation of telomere maintenance via telomerase
GO_0033500Biological processcarbohydrate homeostasis
GO_0060212Biological processnegative regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0043634Biological processpolyadenylation-dependent ncRNA catabolic process
GO_0006364Biological processrRNA processing
GO_0031123Biological processRNA 3'-end processing
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0031499Cellular componentTRAMP complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0070568Molecular functionguanylyltransferase activity
GO_1990817Molecular functionpoly(A) RNA polymerase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0070034Molecular functiontelomerase RNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTENT4B
Protein namePAPD5 protein
Terminal nucleotidyltransferase 4B
Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2)
PAP associated domain containing 5
SynonymsTRF4-2
TUT3
GLD4
PAPD5
DescriptionFUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation . Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) . Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 . Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion . Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation . Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation . .

AccessionsB7ZLC1
E9PC61
Q5EBM7
ENST00000357464.4
A0A7N4YH79
G4U4J3
ENST00000436909.8 [Q8NDF8-5]
ENST00000561678.7
Q8NDF8