TCOF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014029Biological processneural crest formation
GO_0001501Biological processskeletal system development
GO_0042790Biological processnucleolar large rRNA transcription by RNA polymerase I
GO_0014032Biological processneural crest cell development
GO_0006417Biological processregulation of translation
GO_0005730Cellular componentnucleolus
GO_0001650Cellular componentfibrillar center
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0046982Molecular functionprotein heterodimerization activity
GO_0097110Molecular functionscaffold protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTCOF1
Protein nameTreacle ribosome biogenesis factor 1
Treacle protein (Treacher Collins syndrome protein)
Synonyms
DescriptionFUNCTION: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification . Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification . .

AccessionsA0A6I8PRA0
A0A3B3IS06
H0Y8Y7
H0YA99
ENST00000439160.6 [Q13428-7]
A0A2R8Y857
ENST00000513346.5
ENST00000643257.2 [Q13428-3]
ENST00000643812.1
ENST00000427724.7 [Q13428-6]
ENST00000504761.6 [Q13428-1]
ENST00000323668.11 [Q13428-2]
ENST00000377797.7 [Q13428-1]
ENST00000506767.1
ENST00000650162.1
ENST00000646961.1
ENST00000674413.1
A0A2R8Y4M7
H0YAB7
E7ETY2
ENST00000515516.1
Q13428
ENST00000394269.7 [Q13428-5]
ENST00000445265.6 [Q13428-8]
ENST00000513538.2