TBXAS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006690Biological processicosanoid metabolic process
GO_0045907Biological processpositive regulation of vasoconstriction
GO_0019371Biological processcyclooxygenase pathway
GO_0030644Biological processintracellular chloride ion homeostasis
GO_0070542Biological processresponse to fatty acid
GO_0045471Biological processresponse to ethanol
GO_0001516Biological processprostaglandin biosynthetic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004497Molecular functionmonooxygenase activity
GO_0004796Molecular functionthromboxane-A synthase activity
GO_0005506Molecular functioniron ion binding
GO_0016705Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO_0020037Molecular functionheme binding
GO_0036134Molecular function12-hydroxyheptadecatrienoic acid synthase activity
GO_0106256Molecular functionhydroperoxy icosatetraenoate dehydratase activity

IV. Literature review

[source]
Gene nameTBXAS1
Protein nameThromboxane A synthase 1
Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
Thromboxane-A synthase (EC 5.3.99.5) (Cytochrome P450 5A1)
SynonymsTXAS
CYP5
CYP5A1
DescriptionFUNCTION: Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation . Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 . Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE . .

AccessionsENST00000411653.6 [P24557-4]
ENST00000458722.6 [P24557-3]
F8WC80
A0A498U6I9
P24557
C9JS68
ENST00000425687.5 [P24557-2]
ENST00000448866.7 [P24557-1]
ENST00000422328.6
Q86UL7
F8WD37
Q9UDV3
ENST00000438104.6
ENST00000455353.6
ENST00000336425.10 [P24557-1]
ENST00000414041.2