TAF6L report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TAF6L at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TAF6L at tissue level.

III. Associated gene sets

GO_1904672Biological processregulation of somatic stem cell population maintenance
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0006282Biological processregulation of DNA repair
GO_0006338Biological processchromatin remodeling
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0043484Biological processregulation of RNA splicing
GO_0070062Cellular componentextracellular exosome
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0000118Cellular componenthistone deacetylase complex
GO_0046695Cellular componentSLIK (SAGA-like) complex
GO_0000124Cellular componentSAGA complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTAF6L
Protein nameTAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha)
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa, isoform CRA_b (cDNA FLJ57614, highly similar to TAF6-like RNA polymerase IIp300/CBP-associated factor-associated factor 65 kDa subunit 6L)
TATA-box binding protein associated factor 6 like
SynonymsPAF65A
hCG_2016618
DescriptionFUNCTION: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). .

AccessionsQ9Y6J9
E9PK90
B4DVM4
ENST00000525405.5
ENST00000526261.1
ENST00000294168.8
E9PLV8
E9PP94
ENST00000529509.1