TAF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0001541Biological processovarian follicle development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0006282Biological processregulation of DNA repair
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006352Biological processDNA-templated transcription initiation
GO_0071339Cellular componentMLL1 complex
GO_0032991Cellular componentprotein-containing complex
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0033276Cellular componenttranscription factor TFTC complex
GO_0005829Cellular componentcytosol
GO_0001673Cellular componentmale germ cell nucleus
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_0017162Molecular functionaryl hydrocarbon receptor binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTAF4
Protein nameTranscription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135)
Transcription initiation factor TFIID subunit 4
TATA-box binding protein associated factor 4 (Transcription initiation factor TFIID subunit 4)
TATA-box binding protein associated factor 4
SynonymsTAF4A
TAF2C
TAF2C1
TAFII135
TAFII130
DescriptionFUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription . TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) . The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 . TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly . Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone . .

AccessionsV9GY14
A0A0G2JRY5
A0A8I5KW49
ENST00000692470.1
ENST00000628525.2
ENST00000474089.5
O00268
A0A8I5KRH3
V9GY03
ENST00000488539.1
ENST00000252996.9
ENST00000627770.2
ENST00000626682.1
ENST00000609045.1