I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 20% ± 2% | |
| astrocyte | 3 studies | 23% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 20% ± 2% | |
| astrocyte | 3 studies | 23% ± 7% |
Insufficient scRNA-seq data for expression of TADA2A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 1323.57 | 21 / 21 | 100% | 11.81 | 504 / 504 |
| intestine | 100% | 1284.21 | 966 / 966 | 100% | 10.75 | 527 / 527 |
| prostate | 100% | 1263.97 | 245 / 245 | 100% | 9.65 | 502 / 502 |
| thymus | 100% | 1619.37 | 653 / 653 | 100% | 13.79 | 605 / 605 |
| uterus | 100% | 1365.19 | 170 / 170 | 100% | 14.09 | 459 / 459 |
| brain | 100% | 1318.76 | 2641 / 2642 | 100% | 19.49 | 705 / 705 |
| breast | 100% | 1147.27 | 459 / 459 | 100% | 11.46 | 1117 / 1118 |
| ovary | 100% | 1084.07 | 180 / 180 | 100% | 7.27 | 429 / 430 |
| lung | 100% | 1033.30 | 577 / 578 | 100% | 11.27 | 1154 / 1155 |
| stomach | 100% | 860.83 | 359 / 359 | 100% | 9.85 | 285 / 286 |
| skin | 100% | 1244.80 | 1809 / 1809 | 100% | 10.22 | 470 / 472 |
| esophagus | 100% | 1065.20 | 1445 / 1445 | 99% | 8.37 | 182 / 183 |
| pancreas | 100% | 693.42 | 327 / 328 | 99% | 9.33 | 177 / 178 |
| kidney | 100% | 846.02 | 89 / 89 | 98% | 7.79 | 885 / 901 |
| adrenal gland | 100% | 857.19 | 258 / 258 | 96% | 7.84 | 221 / 230 |
| liver | 100% | 630.59 | 226 / 226 | 94% | 4.80 | 382 / 406 |
| adipose | 100% | 1045.22 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1046.42 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 13.33 | 29 / 29 |
| spleen | 100% | 1407.45 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 13.08 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.11 | 1 / 1 |
| muscle | 100% | 1041.02 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 651.67 | 851 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 8.20 | 77 / 80 |
| peripheral blood | 77% | 621.46 | 718 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045995 | Biological process | regulation of embryonic development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0090043 | Biological process | regulation of tubulin deacetylation |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0051302 | Biological process | regulation of cell division |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0070461 | Cellular component | SAGA-type complex |
| GO_0140672 | Cellular component | ATAC complex |
| GO_0000124 | Cellular component | SAGA complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0004402 | Molecular function | histone acetyltransferase activity |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TADA2A |
| Protein name | Transcriptional adapter Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) Transcriptional adaptor 2 (ADA2 homolog, yeast)-like, isoform CRA_c (Transcriptional adaptor 2A) Transcriptional adaptor 2A isoform 2 Transcriptional adaptor 2A Transcriptional adapter 2-alpha Transcriptional adapter 2-alpha (Transcriptional adaptor 2A) Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) |
| Synonyms | TADA2L hCG_28187 KL04P |
| Description | FUNCTION: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity . May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage . . |
| Accessions | ENST00000614122.4 ENST00000632804.1 ENST00000621780.1 ENST00000612272.4 A0A0J9YWZ4 ENST00000619777.4 ENST00000620628.4 O75478 A0A0S2Z4R5 ENST00000632354.1 A0A087WYK3 ENST00000633584.1 [O75478-2] A0A087WZS1 ENST00000633468.1 [O75478-1] ENST00000632146.1 A0A087X2C8 ENST00000615182.5 A0A0S2Z4G1 ENST00000617828.4 [O75478-1] A0A087WU71 ENST00000632358.1 ENST00000614112.4 ENST00000631413.1 ENST00000615328.4 A0A087WTV5 A0A0J9YXZ4 ENST00000620367.4 A0A087WWR4 A0A024R0Y4 ENST00000622522.2 [O75478-1] |
