TAB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010507Biological processnegative regulation of autophagy
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042742Biological processdefense response to bacterium
GO_0010008Cellular componentendosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0043130Molecular functionubiquitin binding
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameTAB3
Protein nameTGF-beta-activated kinase 1 and MAP3K7-binding protein 3
TAK1-binding protein 3, isoform CRA_c (TGF-beta activated kinase 1 (MAP3K7) binding protein 3)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
SynonymsMAP3K7IP3
hCG_1644389
DescriptionFUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) . Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains . The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 . .; FUNCTION: [Isoform 2]: May be an oncogenic factor. .

AccessionsA0A0A0MQY2
ENST00000467136.5
ENST00000378930.7 [Q8N5C8-1]
ENST00000378933.5 [Q8N5C8-1]
F6SS63
ENST00000378932.6 [Q8N5C8-2]
ENST00000288422
ENST00000288422.4 [Q8N5C8-1]
Q8N5C8