Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 9 studies | 25% ± 8% | |
| endothelial cell | 4 studies | 31% ± 15% | |
| neuron | 3 studies | 18% ± 2% | |
| glutamatergic neuron | 3 studies | 29% ± 14% | |
| astrocyte | 3 studies | 24% ± 7% | |
| interneuron | 3 studies | 33% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 26% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 6562.38 | 180 / 180 | 99% | 20.85 | 427 / 430 |
| skin | 100% | 2466.30 | 1804 / 1809 | 98% | 10.84 | 464 / 472 |
| esophagus | 100% | 3079.14 | 1444 / 1445 | 98% | 10.14 | 179 / 183 |
| brain | 98% | 5154.98 | 2577 / 2642 | 100% | 28.46 | 703 / 705 |
| breast | 100% | 2439.26 | 459 / 459 | 94% | 9.41 | 1048 / 1118 |
| thymus | 100% | 3516.87 | 652 / 653 | 90% | 7.32 | 547 / 605 |
| adrenal gland | 100% | 2536.00 | 257 / 258 | 89% | 13.70 | 204 / 230 |
| uterus | 100% | 6527.79 | 170 / 170 | 88% | 8.11 | 405 / 459 |
| stomach | 96% | 2118.47 | 343 / 359 | 93% | 6.79 | 265 / 286 |
| lung | 100% | 3595.64 | 577 / 578 | 86% | 6.47 | 995 / 1155 |
| intestine | 100% | 3355.59 | 962 / 966 | 85% | 5.79 | 448 / 527 |
| bladder | 100% | 3666.48 | 21 / 21 | 81% | 5.40 | 410 / 504 |
| prostate | 100% | 3213.63 | 245 / 245 | 77% | 4.40 | 386 / 502 |
| pancreas | 84% | 984.67 | 274 / 328 | 93% | 7.60 | 166 / 178 |
| kidney | 100% | 1997.98 | 89 / 89 | 74% | 5.16 | 669 / 901 |
| spleen | 100% | 3474.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.22 | 1 / 1 |
| blood vessel | 100% | 3092.68 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2502.90 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 9.36 | 79 / 80 |
| heart | 89% | 1324.81 | 766 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 73% | 4.78 | 33 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 66% | 5.72 | 19 / 29 |
| peripheral blood | 60% | 1036.84 | 556 / 929 | 0% | 0 | 0 / 0 |
| liver | 22% | 208.98 | 50 / 226 | 18% | 1.08 | 74 / 406 |
| muscle | 12% | 111.26 | 100 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007265 | Biological process | Ras protein signal transduction |
| GO_0048169 | Biological process | regulation of long-term neuronal synaptic plasticity |
| GO_0050771 | Biological process | negative regulation of axonogenesis |
| GO_0008542 | Biological process | visual learning |
| GO_0046580 | Biological process | negative regulation of Ras protein signal transduction |
| GO_0043113 | Biological process | receptor clustering |
| GO_0007409 | Biological process | axonogenesis |
| GO_0051402 | Biological process | neuron apoptotic process |
| GO_0048167 | Biological process | regulation of synaptic plasticity |
| GO_0098880 | Biological process | maintenance of postsynaptic specialization structure |
| GO_0043408 | Biological process | regulation of MAPK cascade |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0016358 | Biological process | dendrite development |
| GO_0050803 | Biological process | regulation of synapse structure or activity |
| GO_0007389 | Biological process | pattern specification process |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043198 | Cellular component | dendritic shaft |
| GO_0005829 | Cellular component | cytosol |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0005096 | Molecular function | GTPase activator activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0017124 | Molecular function | SH3 domain binding |
| Gene name | SYNGAP1 |
| Protein name | SYNGAP1 (Synaptic Ras GTPase activating protein 1 homolog (Rat), isoform CRA_a) Ras/Rap GTPase-activating protein SynGAP Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) Synaptic Ras GTPase activating protein 1 |
| Synonyms | hCG_17529 KIAA1938 |
| Description | FUNCTION: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). . |
| Accessions | ENST00000646630.1 [Q96PV0-1] A0A1U9X8L0 A0A804HJ92 A0A2R8YDS2 ENST00000293748.9 A0A0A0MQZ2 B7ZCA0 ENST00000449372.7 ENST00000414753.6 [Q96PV0-3] Q96PV0 ENST00000629380.3 [Q96PV0-1] ENST00000418600.7 [Q96PV0-2] ENST00000682587.1 ENST00000628646.2 [Q96PV0-4] A0A140T8W4 ENST00000355818.3 ENST00000395071.6 [Q96PV0-4] A0A2R8Y6T2 A0A1B0GW70 ENST00000644458.1 ENST00000645250.1 ENST00000638142.2 ENST00000455687.6 [Q96PV0-1] ENST00000428982.4 [Q96PV0-3] |
