SYNGAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0048169Biological processregulation of long-term neuronal synaptic plasticity
GO_0050771Biological processnegative regulation of axonogenesis
GO_0008542Biological processvisual learning
GO_0046580Biological processnegative regulation of Ras protein signal transduction
GO_0043113Biological processreceptor clustering
GO_0007409Biological processaxonogenesis
GO_0051402Biological processneuron apoptotic process
GO_0048167Biological processregulation of synaptic plasticity
GO_0098880Biological processmaintenance of postsynaptic specialization structure
GO_0043408Biological processregulation of MAPK cascade
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0016358Biological processdendrite development
GO_0050803Biological processregulation of synapse structure or activity
GO_0007389Biological processpattern specification process
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0043198Cellular componentdendritic shaft
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameSYNGAP1
Protein nameSYNGAP1 (Synaptic Ras GTPase activating protein 1 homolog (Rat), isoform CRA_a)
Ras/Rap GTPase-activating protein SynGAP
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Synaptic Ras GTPase activating protein 1
SynonymshCG_17529
KIAA1938
DescriptionFUNCTION: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). .

AccessionsENST00000646630.1 [Q96PV0-1]
A0A1U9X8L0
A0A804HJ92
A0A2R8YDS2
ENST00000293748.9
A0A0A0MQZ2
B7ZCA0
ENST00000449372.7
ENST00000414753.6 [Q96PV0-3]
Q96PV0
ENST00000629380.3 [Q96PV0-1]
ENST00000418600.7 [Q96PV0-2]
ENST00000682587.1
ENST00000628646.2 [Q96PV0-4]
A0A140T8W4
ENST00000355818.3
ENST00000395071.6 [Q96PV0-4]
A0A2R8Y6T2
A0A1B0GW70
ENST00000644458.1
ENST00000645250.1
ENST00000638142.2
ENST00000455687.6 [Q96PV0-1]
ENST00000428982.4 [Q96PV0-3]