SYMPK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032091Biological processnegative regulation of protein binding
GO_0006397Biological processmRNA processing
GO_0007155Biological processcell adhesion
GO_0097165Cellular componentnuclear stress granule
GO_0005847Cellular componentmRNA cleavage and polyadenylation specificity factor complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005856Cellular componentcytoskeleton
GO_0016604Cellular componentnuclear body
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSYMPK
Protein nameSymplekin
SYMPK variant protein
Symplekin scaffold protein
SYMPK protein
Synonymsprotein
SPK
variant
DescriptionFUNCTION: Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. .

AccessionsENST00000594293.5
ENST00000599814.5
M0R180
A0A087WUE9
ENST00000599460.5
Q4LE61
Q92797
Q96B47
M0R3C7
M0R039
ENST00000598059.5
ENST00000245934.12 [Q92797-1]
M0R1C2
M0QXP5
ENST00000600237.5
ENST00000602061.5
ENST00000601600.1
M0R033
ENST00000596824.1