SVBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010596Biological processnegative regulation of endothelial cell migration
GO_1905048Biological processregulation of metallopeptidase activity
GO_0061564Biological processaxon development
GO_0006508Biological processproteolysis
GO_0009306Biological processprotein secretion
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0005856Cellular componentcytoskeleton
GO_0005576Cellular componentextracellular region
GO_0045177Cellular componentapical part of cell
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0016504Molecular functionpeptidase activator activity
GO_0008017Molecular functionmicrotubule binding

IV. Literature review

[source]
Gene nameSVBP
Protein nameSmall vasohibin-binding protein (Coiled coil domain-containing protein 23)
SynonymsCCDC23
DescriptionFUNCTION: Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin . This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning . Also required to enhance the solubility and secretion of VASH1 and VASH2 . Plays a role in axon and excitatory synapse formation . .

AccessionsENST00000372522.5
Q8N300
ENST00000372521.9