Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 11 studies | 23% ± 6% | |
| CD8-positive, alpha-beta T cell | 6 studies | 16% ± 1% | |
| CD16-positive, CD56-dim natural killer cell, human | 5 studies | 20% ± 4% | |
| capillary endothelial cell | 5 studies | 30% ± 8% | |
| natural killer cell | 5 studies | 19% ± 2% | |
| endothelial cell of artery | 5 studies | 35% ± 13% | |
| astrocyte | 5 studies | 30% ± 12% | |
| epithelial cell | 4 studies | 26% ± 8% | |
| regulatory T cell | 4 studies | 18% ± 3% | |
| macrophage | 4 studies | 20% ± 2% | |
| classical monocyte | 3 studies | 19% ± 3% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 20% ± 3% | |
| basal cell | 3 studies | 19% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3282.45 | 1445 / 1445 | 100% | 56.67 | 183 / 183 |
| liver | 100% | 2052.07 | 226 / 226 | 100% | 26.05 | 406 / 406 |
| pancreas | 100% | 2011.89 | 328 / 328 | 100% | 38.37 | 178 / 178 |
| skin | 100% | 3436.01 | 1809 / 1809 | 100% | 38.51 | 472 / 472 |
| thymus | 100% | 3946.83 | 653 / 653 | 100% | 36.09 | 604 / 605 |
| brain | 100% | 2838.45 | 2637 / 2642 | 100% | 41.49 | 705 / 705 |
| uterus | 100% | 4093.71 | 170 / 170 | 100% | 52.02 | 458 / 459 |
| lung | 100% | 5531.60 | 578 / 578 | 100% | 38.33 | 1150 / 1155 |
| intestine | 100% | 3506.56 | 966 / 966 | 99% | 34.33 | 524 / 527 |
| prostate | 100% | 4004.33 | 245 / 245 | 99% | 27.03 | 499 / 502 |
| stomach | 100% | 3009.89 | 359 / 359 | 99% | 38.81 | 284 / 286 |
| adrenal gland | 100% | 4813.95 | 258 / 258 | 99% | 44.75 | 228 / 230 |
| kidney | 100% | 2889.44 | 89 / 89 | 99% | 25.08 | 891 / 901 |
| bladder | 100% | 3346.90 | 21 / 21 | 99% | 41.40 | 498 / 504 |
| breast | 100% | 4061.00 | 459 / 459 | 99% | 53.64 | 1103 / 1118 |
| ovary | 100% | 3737.56 | 180 / 180 | 99% | 22.82 | 424 / 430 |
| adipose | 100% | 3741.61 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 33.79 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 38.76 | 29 / 29 |
| spleen | 100% | 5848.31 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 29.69 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 18.64 | 1 / 1 |
| blood vessel | 100% | 2773.03 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 1655.06 | 854 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 3931.27 | 920 / 929 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1829.31 | 792 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0006839 | Biological process | mitochondrial transport |
| GO_0006701 | Biological process | progesterone biosynthetic process |
| GO_0099044 | Biological process | vesicle tethering to endoplasmic reticulum |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0008202 | Biological process | steroid metabolic process |
| GO_0030301 | Biological process | cholesterol transport |
| GO_0031902 | Cellular component | late endosome membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0140284 | Cellular component | endoplasmic reticulum-endosome membrane contact site |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0044232 | Cellular component | organelle membrane contact site |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005768 | Cellular component | endosome |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0015485 | Molecular function | cholesterol binding |
| GO_0120020 | Molecular function | cholesterol transfer activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | STARD3 |
| Protein name | StAR related lipid transfer domain containing 3 StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3) |
| Synonyms | CAB1 MLN64 |
| Description | FUNCTION: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes . The sterol transport mechanism is triggered by phosphorylation of FFAT motif that leads to membrane tethering between the endoplasmic reticulum and late endosomes via interaction with VAPA and VAPB . Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes . May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane . However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes . Does not activate transcriptional cholesterol sensing . Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina . . |
| Accessions | ENST00000583884.5 ENST00000581894.5 J3KSH0 J3KSL3 C9J555 J3QS10 ENST00000579479.5 J3KT87 J3QLM1 ENST00000443521.1 Q14849 ENST00000580331.5 J3QRM3 J3QLA7 ENST00000583718.5 ENST00000580611.5 ENST00000577248.5 ENST00000394250.8 [Q14849-2] ENST00000336308.10 [Q14849-1] J3QLS1 ENST00000583419.5 J3QRG8 ENST00000544210.6 [Q14849-3] ENST00000578577.5 |