STARD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008203Biological processcholesterol metabolic process
GO_0006839Biological processmitochondrial transport
GO_0006701Biological processprogesterone biosynthetic process
GO_0099044Biological processvesicle tethering to endoplasmic reticulum
GO_0006629Biological processlipid metabolic process
GO_0008202Biological processsteroid metabolic process
GO_0030301Biological processcholesterol transport
GO_0031902Cellular componentlate endosome membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0140284Cellular componentendoplasmic reticulum-endosome membrane contact site
GO_0005654Cellular componentnucleoplasm
GO_0044232Cellular componentorganelle membrane contact site
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0015485Molecular functioncholesterol binding
GO_0120020Molecular functioncholesterol transfer activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTARD3
Protein nameStAR related lipid transfer domain containing 3
StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3)
SynonymsCAB1
MLN64
DescriptionFUNCTION: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes . The sterol transport mechanism is triggered by phosphorylation of FFAT motif that leads to membrane tethering between the endoplasmic reticulum and late endosomes via interaction with VAPA and VAPB . Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes . May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane . However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes . Does not activate transcriptional cholesterol sensing . Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina . .

AccessionsENST00000583884.5
ENST00000581894.5
J3KSH0
J3KSL3
C9J555
J3QS10
ENST00000579479.5
J3KT87
J3QLM1
ENST00000443521.1
Q14849
ENST00000580331.5
J3QRM3
J3QLA7
ENST00000583718.5
ENST00000580611.5
ENST00000577248.5
ENST00000394250.8 [Q14849-2]
ENST00000336308.10 [Q14849-1]
J3QLS1
ENST00000583419.5
J3QRG8
ENST00000544210.6 [Q14849-3]
ENST00000578577.5