ST8SIA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0005975Biological processcarbohydrate metabolic process
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0034605Biological processcellular response to heat
GO_0009311Biological processoligosaccharide metabolic process
GO_0006491Biological processN-glycan processing
GO_0006486Biological processprotein glycosylation
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0003828Molecular functionalpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO_0008373Molecular functionsialyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameST8SIA1
Protein nameAlpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.3.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI)
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1 protein)
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
SynonymsSIAT8A
SIAT8
DescriptionFUNCTION: Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid . Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3 . Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively . Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells . .

AccessionsF8WCS8
ENST00000540824.5
Q92185
Q86X71
ENST00000541868.1
ENST00000396037.9 [Q92185-1]
H0YFU1
H0YGV9
ENST00000404299.3
ENST00000538256.1
ENST00000261197.7 [Q92185-2]
ENST00000381424.3
H0YG41