ST6GALNAC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006687Biological processglycosphingolipid metabolic process
GO_0001574Biological processganglioside biosynthetic process
GO_0009100Biological processglycoprotein metabolic process
GO_0019082Biological processviral protein processing
GO_0009311Biological processoligosaccharide metabolic process
GO_0006677Biological processglycosylceramide metabolic process
GO_0006486Biological processprotein glycosylation
GO_0000139Cellular componentGolgi membrane
GO_0005654Cellular componentnucleoplasm
GO_0047290Molecular functionalpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
GO_0001665Molecular functionalpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO_0008373Molecular functionsialyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameST6GALNAC3
Protein nameAlpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC 2.4.3.7) (GalNAc alpha-2,6-sialyltransferase III) (ST6GalNAc III) (ST6GalNAcIII) (STY) (Sialyltransferase 7C) (SIAT7-C)
SynonymsSIAT7C
UNQ2787/PRO7177
DescriptionFUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b . GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity . .

AccessionsQ8NDV1
ENST00000328299.4 [Q8NDV1-1]