SSX2IP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007098Biological processcentrosome cycle
GO_0060271Biological processcilium assembly
GO_0007155Biological processcell adhesion
GO_0035020Biological processregulation of Rac protein signal transduction
GO_0035735Biological processintraciliary transport involved in cilium assembly
GO_2000145Biological processregulation of cell motility
GO_0032991Cellular componentprotein-containing complex
GO_0036064Cellular componentciliary basal body
GO_0005912Cellular componentadherens junction
GO_0034451Cellular componentcentriolar satellite
GO_0005737Cellular componentcytoplasm
GO_0031252Cellular componentcell leading edge
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSSX2IP
Protein nameSSX family member 2 interacting protein
Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein)
SynonymsKIAA0923
DescriptionFUNCTION: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome . Involved in ciliogenesis . It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia . .

AccessionsENST00000342203.8 [Q9Y2D8-1]
S4R403
Q9Y2D8
ENST00000603677.1
ENST00000437941.6 [Q9Y2D8-3]
C9JIX7
S4R2Y6
ENST00000476905.6
ENST00000605755.5 [Q9Y2D8-3]
ENST00000481102.5 [Q9Y2D8-2]
ENST00000422026.1