SRRM4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043484Biological processregulation of RNA splicing
GO_0007605Biological processsensory perception of sound
GO_0042551Biological processneuron maturation
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0030154Biological processcell differentiation
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0007399Biological processnervous system development
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding

IV. Literature review

[source]
Gene nameSRRM4
Protein nameSerine/arginine repetitive matrix 4
Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100)
SynonymsKIAA1853
DescriptionFUNCTION: Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells . Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity). .

AccessionsENST00000267260.5
ENST00000641899.1
V5T9A0
A0A286YF08
A7MD48