Insufficient scRNA-seq data for expression of SRD5A2 at single-cell level.
Insufficient scRNA-seq data for expression of SRD5A2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 3198.82 | 245 / 245 | 90% | 11.59 | 453 / 502 |
liver | 100% | 2428.08 | 226 / 226 | 68% | 11.27 | 275 / 406 |
lung | 74% | 120.03 | 429 / 578 | 23% | 1.18 | 267 / 1155 |
bladder | 81% | 311.90 | 17 / 21 | 8% | 0.59 | 41 / 504 |
kidney | 80% | 29.33 | 71 / 89 | 2% | 0.06 | 16 / 901 |
muscle | 81% | 23.94 | 647 / 803 | 0% | 0 | 0 / 0 |
breast | 54% | 18.70 | 247 / 459 | 12% | 0.44 | 133 / 1118 |
uterus | 45% | 56.52 | 76 / 170 | 10% | 0.64 | 47 / 459 |
adrenal gland | 44% | 5.50 | 114 / 258 | 0% | 0.01 | 1 / 230 |
ovary | 26% | 4.49 | 47 / 180 | 14% | 0.58 | 59 / 430 |
skin | 28% | 4.73 | 507 / 1809 | 5% | 0.12 | 23 / 472 |
brain | 26% | 4.50 | 687 / 2642 | 5% | 0.22 | 35 / 705 |
stomach | 29% | 3.77 | 103 / 359 | 0% | 0.00 | 1 / 286 |
adipose | 26% | 9.75 | 310 / 1204 | 0% | 0 | 0 / 0 |
spleen | 24% | 4.29 | 57 / 241 | 0% | 0 | 0 / 0 |
esophagus | 9% | 1.42 | 134 / 1445 | 2% | 0.06 | 3 / 183 |
thymus | 9% | 1.30 | 61 / 653 | 1% | 0.03 | 6 / 605 |
peripheral blood | 8% | 3.48 | 73 / 929 | 0% | 0 | 0 / 0 |
intestine | 5% | 0.95 | 48 / 966 | 1% | 0.08 | 7 / 527 |
blood vessel | 5% | 0.70 | 71 / 1335 | 0% | 0 | 0 / 0 |
pancreas | 3% | 0.46 | 10 / 328 | 2% | 0.23 | 4 / 178 |
heart | 2% | 0.23 | 17 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 1% | 0.01 | 1 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0033574 | Biological process | response to testosterone |
GO_0021766 | Biological process | hippocampus development |
GO_0008209 | Biological process | androgen metabolic process |
GO_0030540 | Biological process | female genitalia development |
GO_0043434 | Biological process | response to peptide hormone |
GO_0061370 | Biological process | testosterone biosynthetic process |
GO_0006694 | Biological process | steroid biosynthetic process |
GO_0007267 | Biological process | cell-cell signaling |
GO_0031667 | Biological process | response to nutrient levels |
GO_0032354 | Biological process | response to follicle-stimulating hormone |
GO_0030539 | Biological process | male genitalia development |
GO_0030154 | Biological process | cell differentiation |
GO_0006702 | Biological process | androgen biosynthetic process |
GO_0018963 | Biological process | phthalate metabolic process |
GO_0006706 | Biological process | steroid catabolic process |
GO_0008584 | Biological process | male gonad development |
GO_0018879 | Biological process | biphenyl metabolic process |
GO_0048545 | Biological process | response to steroid hormone |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0060348 | Biological process | bone development |
GO_0018894 | Biological process | dibenzo-p-dioxin metabolic process |
GO_0021854 | Biological process | hypothalamus development |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0070852 | Cellular component | cell body fiber |
GO_0043025 | Cellular component | neuronal cell body |
GO_0003865 | Molecular function | 3-oxo-5-alpha-steroid 4-dehydrogenase activity |
GO_0030283 | Molecular function | testosterone dehydrogenase [NAD(P)+] activity |
GO_0033218 | Molecular function | amide binding |
GO_0047751 | Molecular function | 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SRD5A2 |
Protein name | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.22) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) (Type II 5-alpha reductase) |
Synonyms | |
Description | FUNCTION: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. . |
Accessions | P31213 ENST00000622030.2 |