SPTSSB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPTSSB at tissue level.

III. Associated gene sets

GO_0007029Biological processendoplasmic reticulum organization
GO_0030148Biological processsphingolipid biosynthetic process
GO_1904220Biological processregulation of serine C-palmitoyltransferase activity
GO_0046512Biological processsphingosine biosynthetic process
GO_0046513Biological processceramide biosynthetic process
GO_0017059Cellular componentserine palmitoyltransferase complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0004758Molecular functionserine C-palmitoyltransferase activity

IV. Literature review

[source]
Gene nameSPTSSB
Protein nameSerine palmitoyltransferase small subunit B (Protein ADMP) (Small subunit of serine palmitoyltransferase B) (ssSPTb)
SynonymsC3orf57
ADMP
SSSPTB
DescriptionFUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases . The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core . Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference . .

AccessionsQ8NFR3
ENST00000497137.1
ENST00000620149.2
ENST00000359175.9