SPTLC3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPTLC3 at tissue level.

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0046520Biological processsphingoid biosynthetic process
GO_0046512Biological processsphingosine biosynthetic process
GO_0046513Biological processceramide biosynthetic process
GO_0017059Cellular componentserine palmitoyltransferase complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0004758Molecular functionserine C-palmitoyltransferase activity
GO_0030170Molecular functionpyridoxal phosphate binding

IV. Literature review

[source]
Gene nameSPTLC3
Protein nameSerine palmitoyltransferase long chain base subunit 3 (Serine palmitoyltransferase, long chain base subunit 2-like (Aminotransferase 2))
Serine palmitoyltransferase long chain base subunit 3
Serine palmitoyltransferase 3 (EC 2.3.1.50) (Long chain base biosynthesis protein 2b) (LCB2b) (Long chain base biosynthesis protein 3) (LCB 3) (Serine-palmitoyl-CoA transferase 3) (SPT 3)
SynonymsRP5-1077I2.1-002
C20orf38
SPTLC2L
RP5-1077I2.1-001
DescriptionFUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases . The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference . The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference . .

AccessionsQ9NUV7
ENST00000431275.1
ENST00000399002.7 [Q9NUV7-1]
B1AKS3
ENST00000434210.5
B1AKS2
H0Y733
ENST00000450297.1