SPRED2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010801Biological processnegative regulation of peptidyl-threonine phosphorylation
GO_1902747Biological processnegative regulation of lens fiber cell differentiation
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0090311Biological processregulation of protein deacetylation
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0043517Biological processpositive regulation of DNA damage response, signal transduction by p53 class mediator
GO_0030658Cellular componenttransport vesicle membrane
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding
GO_0005173Molecular functionstem cell factor receptor binding

IV. Literature review

[source]
Gene nameSPRED2
Protein nameSprouty-related, EVH1 domain-containing protein 2 (Spred-2)
Sprouty-related, EVH1 domain-containing protein 2
Sprouty related EVH1 domain containing 2
Synonyms
DescriptionFUNCTION: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases . Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras . Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). .

AccessionsENST00000421087.5
H7C2T4
Q7Z698
ENST00000452315.5
ENST00000356388.9 [Q7Z698-1]
ENST00000440972.1
H7C065
ENST00000427238.1
ENST00000426832.1
C9J623
H7C3Y6
C9JG63
ENST00000443619.6 [Q7Z698-2]