Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 19 studies | 30% ± 11% | |
| astrocyte | 15 studies | 33% ± 15% | |
| oligodendrocyte precursor cell | 12 studies | 40% ± 16% | |
| glutamatergic neuron | 9 studies | 38% ± 26% | |
| fibroblast | 9 studies | 29% ± 10% | |
| GABAergic neuron | 8 studies | 38% ± 23% | |
| pericyte | 8 studies | 27% ± 5% | |
| microglial cell | 8 studies | 25% ± 7% | |
| macrophage | 6 studies | 27% ± 8% | |
| neuron | 5 studies | 34% ± 20% | |
| interneuron | 5 studies | 35% ± 16% | |
| club cell | 5 studies | 25% ± 8% | |
| type I pneumocyte | 5 studies | 28% ± 4% | |
| type II pneumocyte | 5 studies | 29% ± 5% | |
| adipocyte | 4 studies | 22% ± 7% | |
| epithelial cell | 4 studies | 28% ± 11% | |
| retina horizontal cell | 4 studies | 19% ± 3% | |
| basal cell | 4 studies | 40% ± 13% | |
| Mueller cell | 3 studies | 20% ± 2% | |
| endothelial cell of lymphatic vessel | 3 studies | 19% ± 3% | |
| endothelial cell of vascular tree | 3 studies | 27% ± 9% | |
| hepatocyte | 3 studies | 42% ± 22% | |
| smooth muscle cell | 3 studies | 25% ± 9% | |
| abnormal cell | 3 studies | 37% ± 14% | |
| capillary endothelial cell | 3 studies | 23% ± 3% | |
| goblet cell | 3 studies | 36% ± 16% | |
| mesothelial cell | 3 studies | 21% ± 4% | |
| mucus secreting cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1841.38 | 1445 / 1445 | 100% | 42.75 | 183 / 183 |
| stomach | 100% | 1665.07 | 359 / 359 | 99% | 33.16 | 284 / 286 |
| skin | 100% | 2478.14 | 1807 / 1809 | 99% | 54.41 | 469 / 472 |
| intestine | 100% | 1992.23 | 966 / 966 | 99% | 32.67 | 522 / 527 |
| lung | 100% | 3379.12 | 578 / 578 | 99% | 37.75 | 1144 / 1155 |
| thymus | 100% | 3393.40 | 653 / 653 | 99% | 43.40 | 596 / 605 |
| ovary | 100% | 2369.09 | 180 / 180 | 98% | 36.11 | 423 / 430 |
| brain | 100% | 2075.79 | 2632 / 2642 | 99% | 40.75 | 695 / 705 |
| bladder | 100% | 2118.43 | 21 / 21 | 98% | 28.79 | 494 / 504 |
| pancreas | 99% | 1332.46 | 326 / 328 | 98% | 28.31 | 175 / 178 |
| breast | 100% | 4087.54 | 459 / 459 | 97% | 47.70 | 1086 / 1118 |
| kidney | 100% | 2098.03 | 89 / 89 | 92% | 24.99 | 829 / 901 |
| prostate | 100% | 2385.20 | 245 / 245 | 91% | 18.79 | 459 / 502 |
| adrenal gland | 100% | 1447.30 | 258 / 258 | 88% | 21.39 | 203 / 230 |
| uterus | 100% | 2989.44 | 170 / 170 | 87% | 21.62 | 401 / 459 |
| liver | 100% | 1403.11 | 226 / 226 | 83% | 15.59 | 339 / 406 |
| adipose | 100% | 4048.73 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 28.71 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 19.65 | 1 / 1 |
| blood vessel | 100% | 2674.24 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 1548.98 | 857 / 861 | 0% | 0 | 0 / 0 |
| spleen | 98% | 938.05 | 236 / 241 | 0% | 0 | 0 / 0 |
| muscle | 93% | 794.58 | 746 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 17.85 | 38 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 72% | 19.23 | 21 / 29 |
| peripheral blood | 17% | 145.25 | 159 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0010801 | Biological process | negative regulation of peptidyl-threonine phosphorylation |
| GO_1902747 | Biological process | negative regulation of lens fiber cell differentiation |
| GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
| GO_0090311 | Biological process | regulation of protein deacetylation |
| GO_0010719 | Biological process | negative regulation of epithelial to mesenchymal transition |
| GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO_0043409 | Biological process | negative regulation of MAPK cascade |
| GO_0043517 | Biological process | positive regulation of DNA damage response, signal transduction by p53 class mediator |
| GO_0030658 | Cellular component | transport vesicle membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030291 | Molecular function | protein serine/threonine kinase inhibitor activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005173 | Molecular function | stem cell factor receptor binding |
| Gene name | SPRED2 |
| Protein name | Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) Sprouty-related, EVH1 domain-containing protein 2 Sprouty related EVH1 domain containing 2 |
| Synonyms | |
| Description | FUNCTION: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases . Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras . Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). . |
| Accessions | ENST00000421087.5 H7C2T4 Q7Z698 ENST00000452315.5 ENST00000356388.9 [Q7Z698-1] ENST00000440972.1 H7C065 ENST00000427238.1 ENST00000426832.1 C9J623 H7C3Y6 C9JG63 ENST00000443619.6 [Q7Z698-2] |