SPPL2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031293Biological processmembrane protein intracellular domain proteolysis
GO_0033619Biological processmembrane protein proteolysis
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0050776Biological processregulation of immune response
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0098554Cellular componentcytoplasmic side of endoplasmic reticulum membrane
GO_0000139Cellular componentGolgi membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0098553Cellular componentlumenal side of endoplasmic reticulum membrane
GO_0010008Cellular componentendosome membrane
GO_0030660Cellular componentGolgi-associated vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0042500Molecular functionaspartic endopeptidase activity, intramembrane cleaving
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPPL2B
Protein nameSignal peptide peptidase like 2B
Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)
SynonymsIMP4
PSL1
KIAA1532
DescriptionFUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing . Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus . May play a role in the regulation of innate and adaptive immunity . Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis . .

AccessionsENST00000618220.4 [Q8TCT7-2]
A0A087WZ50
ENST00000613503.5 [Q8TCT7-1]
A0A087WWL4
ENST00000614794.4
ENST00000586332.5
ENST00000621568.4
Q8TCT7
A0A087WZ93
ENST00000610743.4 [Q8TCT7-4]
ENST00000612623.1
A0A087WT77