SPINK5 | OmnibusX

Name	Number of supported studies	Average coverage
esophagus	3 studies	45% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	40%	56522.70	581 / 1445	88%	132.41	161 / 183
ureter	0%	0	0 / 0	100%	6.18	1 / 1
skin	72%	25418.03	1299 / 1809	28%	13.89	131 / 472
tonsil	0%	0	0 / 0	98%	138.52	44 / 45
lung	0%	0	0 / 578	77%	20.51	894 / 1155
pancreas	0%	16.31	1 / 328	74%	7.44	132 / 178
uterus	2%	2086.38	3 / 170	72%	58.70	329 / 459
bladder	0%	0	0 / 21	66%	11.85	332 / 504
intestine	1%	28.05	9 / 966	61%	16.19	319 / 527
stomach	1%	257.15	3 / 359	53%	5.17	152 / 286
ovary	0%	0	0 / 180	41%	1.75	177 / 430
thymus	2%	71.78	15 / 653	32%	2.28	196 / 605
kidney	0%	0	0 / 89	28%	2.29	252 / 901
prostate	1%	28.69	2 / 245	23%	1.68	117 / 502
liver	0%	0	0 / 226	14%	0.67	56 / 406
breast	0%	7.39	1 / 459	11%	1.09	122 / 1118
lymph node	0%	0	0 / 0	3%	0.21	1 / 29
adrenal gland	0%	0	0 / 258	2%	0.10	4 / 230
eye	0%	0	0 / 0	1%	0.28	1 / 80
adipose	1%	54.51	7 / 1204	0%	0	0 / 0
brain	0%	0	0 / 2642	0%	0.02	3 / 705
muscle	0%	24.72	2 / 803	0%	0	0 / 0
heart	0%	2.98	1 / 861	0%	0	0 / 0
blood vessel	0%	11.47	1 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

GO_0045580	Biological process	regulation of T cell differentiation
GO_1902572	Biological process	negative regulation of serine-type peptidase activity
GO_0030855	Biological process	epithelial cell differentiation
GO_0007275	Biological process	multicellular organism development
GO_0030198	Biological process	extracellular matrix organization
GO_0050777	Biological process	negative regulation of immune response
GO_0035315	Biological process	hair cell differentiation
GO_0009913	Biological process	epidermal cell differentiation
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0002787	Biological process	negative regulation of antibacterial peptide production
GO_0045861	Biological process	negative regulation of proteolysis
GO_0030154	Biological process	cell differentiation
GO_0051884	Biological process	regulation of timing of anagen
GO_0007417	Biological process	central nervous system development
GO_0030155	Biological process	regulation of cell adhesion
GO_0005576	Cellular component	extracellular region
GO_0097209	Cellular component	epidermal lamellar body
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0004867	Molecular function	serine-type endopeptidase inhibitor activity

Gene name	SPINK5
Protein name	Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665] Serine peptidase inhibitor Kazal type 5
Synonyms
Description	FUNCTION: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. .
Accessions	E5RG22 ENST00000359874.7 [Q9NQ38-3] E7EWP9 ENST00000508733.5 E5RFU9 ENST00000256084.8 [Q9NQ38-1] ENST00000476697.7 ENST00000521206.5 Q9NQ38 ENST00000398454.5 [Q9NQ38-2]

SPINK5 report