SPHK2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SPHK2 at single-cell level.

II. Expression across tissues

III. Associated gene sets

GO_0043306Biological processpositive regulation of mast cell degranulation
GO_0030148Biological processsphingolipid biosynthetic process
GO_1904628Biological processcellular response to phorbol 13-acetate 12-myristate
GO_0006669Biological processsphinganine-1-phosphate biosynthetic process
GO_0006670Biological processsphingosine metabolic process
GO_0008283Biological processcell population proliferation
GO_1904959Biological processregulation of cytochrome-c oxidase activity
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0032736Biological processpositive regulation of interleukin-13 production
GO_0090280Biological processpositive regulation of calcium ion import
GO_1903426Biological processregulation of reactive oxygen species biosynthetic process
GO_2001169Biological processregulation of ATP biosynthetic process
GO_2000304Biological processpositive regulation of ceramide biosynthetic process
GO_0003376Biological processsphingosine-1-phosphate receptor signaling pathway
GO_0046512Biological processsphingosine biosynthetic process
GO_0001568Biological processblood vessel development
GO_0090037Biological processpositive regulation of protein kinase C signaling
GO_0007420Biological processbrain development
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0016310Biological processphosphorylation
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0033008Biological processpositive regulation of mast cell activation involved in immune response
GO_0043065Biological processpositive regulation of apoptotic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0030308Biological processnegative regulation of cell growth
GO_0000786Cellular componentnucleosome
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0017050Molecular functionD-erythro-sphingosine kinase activity
GO_0031267Molecular functionsmall GTPase binding
GO_0001727Molecular functionlipid kinase activity
GO_0038036Molecular functionsphingosine-1-phosphate receptor activity
GO_0008481Molecular functionsphinganine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPHK2
Protein nameSphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91)
Sphingosine kinase 2
SynonymsSK2
hCG_15274
DescriptionFUNCTION: Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides . In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis . In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration . In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 . In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle . In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). .

AccessionsENST00000599029.2
ENST00000245222.9 [Q9NRA0-1]
ENST00000340932.7
E7ET12
ENST00000598088.5 [Q9NRA0-1]
ENST00000600537.5 [Q9NRA0-4]
ENST00000593308.1
Q9NRA0
E9PCV4
ENST00000599748.5 [Q9NRA0-2]
ENST00000597434.5
A0A075B7A1
ENST00000601712.5
ENST00000426514.2
M0QZP3
M0R344
M0R0E9
M0QXX5
ENST00000601704.1